Bio Reactor and Bioprocess Plant Design
Conducted by Dr. Saswata Goswami on March 7, 2024
Dr. Saswata Goswami is Scientist-F as well as Dean Academics in the Center of Innovative and Applied Bioprocessing (CIAB), Mohali, and former Adjunct Faculty of Regional Centre of Biotechnology (RCB), Faridabad
Abstract: The current presentation has a strong emphasis on the Bioprocess design with the given data Accordingly, sizing of the equipment and machinery have been explained thoroughly. Bioprocess design finally determines the Bio reactor design, and its necessary utility. Given a product with desired annual production rate (process throughput), the present discussion on bioprocess design endeavors to explain many process and production queries. It describes appropriate utilities required for a single batch, utilization of the existing facility or any requirement of the new plant. The description also enlightens the way out of the manufacturing cost calculation, maximum production possible with the full plant utilization.
Keywords: Plant machinery, utility, process design, cost calculation
References:
1. Fermentation and Biochemical Engineering Handbook, Principles, Process Design, and Equipment. Second Edition, Edited by Henry C. Vogel
2. Plant Design and Economics For Chemical Engineers, Fourth Edition, Max S. Peters Klaus D. Timmerhaus
3. Preliminary Chemical Engineering Plant Design, William D. Baasel
4. Scale-Up in Chemical Engineering. 2nd Edition. M. Zlokarnik
5. Perry’s Chemical Engineers’ Handbook, 8 th Edition
6. Principles of fermentation technology/Peter F. Stanbury, Allan Whitaker, Stephen J. Hall. - 2nd ed.
7. Unit Operations of Chemical Engineering, McCabe, Smith, and Harriott: 7th Edition
Shake Flask to Fermenter: An Overview
Conducted by Dr. Saswata Goswami on March 6, 2024
Dr. Saswata Goswami is Scientist-F as well as Dean Academics in the Center of Innovative and Applied Bioprocessing (CIAB), Mohali, and former Adjunct Faculty of Regional Centre of Biotechnology (RCB), Faridabad
Abstract: The current presentation has a strong emphasis on the shake flask studies and its up scaling application towards large scale process. The conceptualization of shake flask studies at the earlier and the beginning days of Biochemical Engineering were discussed as the introduction. Further as the discussion spreads the mass transfer co efficient, heat transfer phenomena, mixing pattern, shear and its influence on the growth of the microorganism, rheology of the broth have been explained with the proper appropriation. Accordingly type of agitators, their comparison came into. The criteria on scale up studies have been elaborated with many factors taken into consideration. The effect of media composition and their physico chemical properties and consequently the influence on microbial growth kinetics have been emphasized in the presentation. Overall environmental effect determines the decision on up scaling.
Keywords: Biochemical Engineering, Growth Kinetics, Shake Flask studies, Scale Up, Media Composition
References:
1. Fermentation and Biochemical Engineering Handbook, Principles, Process Design, and Equipment. Second Edition, Edited by Henry C. Vogel
2. Principles of fermentation technology/Peter F. Stanbury, Allan Whitaker, Stephen J. Hall. - 2nd ed.
3. Unit Operations of Chemical Engineering, McCabe, Smith, and Harriott: 7th Edition
4. Bioprocess Engineering Principle, Second Edition, Pauline M. Doran
5. Bioprocess Engineering, 2nd edition, Shuler and Kargi.
