A.K. Sharma
Professor
There is an image here
Download Resume
Interests
Protein Biochemistry, Biophysics and Structural Biology
ashwani[dot]sharma[at]bt[dot]iitr[dot]ac[dot]in
--
91-01332-285657
Biosketch
Educational Details
Professional Background
Administrative Positions

Research
Projects
Papers
Books
Collaborations

Honours and Awards
Honors
Memberships

Teaching Engagements
Teaching Engagements

Students
Supervisions
Associate Scholars

Miscellaneous
Events
Visits
Miscellaneous
BioSketch
Educational Details
Jiwaji University, Gwalior
1993
Masters, Biochemistry
All India Institute of Medical Sciences, New Delhi
1999
PhD, Biochemistry and Biophysics
Professional Background
Professor
22 Dec 2018 - Present
Department of Biosciences and Bioengineering, IIT Roorkee
Associate Professor
22 Oct 2012 - 21 Dec 2018
Department of Biosciences and Bioengineering, IIT Roorkee
Assistant Professor
15 Jan 2003 - 21 Oct 2012
Department of Biosciences and Bioengineering, IIT Roorkee
Post-doctoral Research Associate
01 Mar 1999 - 31 Dec 2002
University of North Carolina at Chapel Hill, USA
Administrative Positions
Dean of Faculty Affairs
01 Jun 2022 - Present
Indian Institute of Technology Roorkee
Head of Department of Biosciences and Bioengineering
01 Feb 2018 - 31 Jan 2021
Indian Institute of Technology Roorkee
Staff Adviser
01 Jan 2013 - 01 Jan 2016
Sports Council, IIT Roorkee
Research
Projects
TOPIC START DATE FIELD DESCRIPTION FINANCIAL OUTLAY FUNDING AGENCY OTHER OFFICERS
To develop potential inhibitor molecules against putative cysteine-binding protein from Candidatus Liberibacter asiaticus 14 Jan 2020 Bioinformatics and Structural Biology -- SERB Prof. Pravindra Kumar, IIT Roorkee and Dr. DK Ghosh - ICAR-CCRI, Nagpur
Evaluation of antimicrobial Nano-zinc oxide-2S albumin protein formulation on HLB infected plants. 06 Feb 2020 Antimicrobial studies on HLB infected plants -- SERB-DST Dr. DK Ghosh, ICAR-CCRI Nagpur, PI
Structure-function studies on antioxidant defense system of Candidatus Lliberibacter asiaticus 13 Jan 2016 Protein Biochemistry and Structural Biology -- DBT Dr. DK Ghosh, ICAR-CCRI Nagpur
Bioinformatics and structure-based approach towards developing ... .... as new potential anticancer agents 29 May 2012 Bioinformatics and structural Biology -- CSIR Prof. Partha Roy
Structure-function studies of a trypsin inhibitor purified from seeds of Putranjiva roxburghii 21 May 2009 Protein Biochemistry and Structural Biology -- CSIR Prof. Pravindra Kumar
Structure analysis of a trypsin inhibitor purified from seeds of Murraya koenigii 15 Jul 2008 Protein Biochemistry and Structural Biology -- DST Prof. Pravindra Kumar
Structural studies on squash family proteinase inhibitor from bottle gourd (Lagenaria siceraria) 29 Jun 2004 Protein Biochemistry and Structural Biology -- DST
Enzyme engineering for biodegradation of plasticisers in PPCPs in bioremediation. 01 Jan 2020 Protein Biochemistry and Structural Biology -- DST Prof. Pravindra Kumar as PI
Development of sensor for blast and blight disease and stomatal activity measurement in rice. 01 Jan 2019 Development of sensor -- ICAR Prof. D. Sircar, PI and Prof. P. Roy
Structural characterization of enzymes from shikimate pathways for designing rational inhibitors as antimicrobial molecules. 08 Jan 2019 Structural Biology -- SERB-DST Prof. Pravindra Kumar as PI
Structural characterization of dye-decolorizing peroxidase enzyme from Bacillus subtilis and Pseudomonas putida 13 Jan 2016 Structural Biology -- DBT Prof. Pravindra Kumar as PI
Structural studies of biphenyl dehydrogenase from Comamonas testosteroni strain B-356 01 Jan 2008 Structural Biology -- CSIR Prof. Pravindra Kumar as PI




Papers
A simple cost-effective larval injection method for dsRNA delivery to induce RNAi response in Helicoverpa armigera (Hübner)
2023
Das J, Kumar R, Shah V and Sharma AK | Wiley
Journal: Journal of Applied Entomology Pages: DOI:10.1111/jen.13100 ,
Huanglongbing pandemic: current challenges and emerging management strategies
2023
Ghosh D, Kokane SB, Savita BK, Kumar P, Sharma AK, Ozcan A, Kokane AD, Santra S | MDPI
Journal: Plants Pages: 160 , Volumes: 12(1) ,
PRpnp, a novel dual activity PNP family protein improves plant vigor and confers multiple stress tolerance in Citrus aurantifolia
2023
Singh S, Chaudhary C, Bharsakale R, Gazal S, Verma L, Tarannum Z, Behere G, Giri J, Germain H, Ghosh D Sharma AK and Chauhan H | Wiley
Journal: Plant Biotechnology Journal Pages: DOI: 10.1111/pbi.13989 ,
Functional characterization of chitin synthesis pathway genes, HaAGM and HaUAP, reveal their crucial roles in ecdysis and survival of Helicoverpa armigera (Hübner)
2022
Das J, Kumar R, Shah V and Sharma AK | Elsevier
Journal: Pesticide Biochemistry and Physiology Pages: 105273 , Volumes: 188 ,
Structural insights at acidic pH of dye-decolorizing peroxidase from Bacillus subtilis
2022
Dhankhar P, Dalal V, Sharma AK, Kumar P | Wiley
Journal: Proteins Pages: DOI: 10.1002/prot.26444 ,
Crystal structure and molecular characterization of NADP+-farnesol dehydrogenase from cotton bollworm, Helicoverpa armigera
2022
Kumar R, Das J, Mahto JK, Sharma M, Vivek S, Kumar P, Sharma AK | Elsevier
Journal: Insect Biochemistry and Molecular Biology Pages: 103812 , Volumes: 147 ,
Biochemical characterization and structure-based in silco screening of potent inhibitors against the bacterioferritin comigratory protein family 1 Cys peroxiredoxin from Candidatus Liberibacter asiaticus
2022
Gupta DN, Dalal V, Savita BK, Alam MS, Singh A, Gubyad M, Ghosh DK, Kumar P, Sharma AK | Taylor & Francis
Journal: Journal of Biomolecular Structure and Dynamics Pages: 1-13 ,
SAXS analysis and characterization of anticancer activity of PNPUDP family protein from Putranjiva roxburghii
2022
Verma P, Varshney R, Yadav SPS, Kar B, Roy P, Sharma AK | Springer
Journal: Protein Journal Pages: 381-393 , Volumes: 41(3) ,
Characterization of a cytoplasmic 2-Cys peroxiredoxin from Citrus sinensis and its potential role in protection from oxidative damage and wound healing
2022
Gupta DN, Rani R, Kokane AD, Ghosh DK, Tomar S, Sharma AK | Elsevier
Journal: International Journal of Biological Macromolecules Pages: 1088-1099 , Volumes: 209(Pt A) ,
In silico identification of potential phytochemical inhibitors targeting farnesyl diphosphate synthase of cotton bollworm ( Helicoverpa armigera)
2022
Alam MS, Sharma M, Kumar R, Das J, Rode S, Kumar P, Prasad R, Sharma AK | Taylor and Francis
Journal: Journal of Biomolecular Structure and Dynamics Pages: 1-10 ,
Molecular insights into substrate recognition and catalysis by phthalate dioxygenase from Comamonas testosterone
2021
Mahto JK, Neetu N, Waghmode B, Kuatsjah E, Sharma M, Sircar D, Sharma AK, Tomar S, Eltis LD, Kumar P. | ASBMB
Journal: Journal of Biological Chemistry Pages: 101416 , Volumes: 297(6) ,
Structure of dye-decolorizing peroxidase from Bacillus subtilis in complex with veratryl alcohol
2021
Dhankhar P, Dalal V, Singh V, Sharma AK, Kumar P | Elsevier
Journal: International Journal of Biological macromolecules Pages: 601-608 , Volumes: 193(Pt A) ,
Deciphering the enigma of missing DNA binding domain of LacI family transcription factors
2021
Neetu N, Katiki M, Mahto JK, Sharma M, Narayanan A, Maity S, Tomar S, Ambatipudi K, Sharma AK, Yernool D, Kumar P | Elsevier
Journal: Archives of Biochemistry and Biophysics Pages: 109060 , Volumes: 713 ,
Characterization of recombinant pumpkin 2S albumin and mutation studies to unravel potential DNA/RNA binding site
2021
Savita BK, Dalal V, Choudhary S, Gupta DN, Das N, Tomar S, Kumar P, Roy P, Sharma AK | Elsevier
Journal: Biochemical and Biophysical Research Communications Pages: 28-34 , Volumes: 580 ,
In-silico screening and identification of potential inhibitors against 2Cys peroxiredoxin of Candidatus Liberibacter asiaticus
2021
Gupta DN, Dalal V, Savita BK, Dhankhar P, Ghosh DK, Kumar P, Sharma AK | Taylor and Francis
Journal: Journal of Biomolecular Structure and Dynamics Pages: 8725-8739 , Volumes: 40(19) ,
A molecular docking and dynamic approach to screen inhibitors against ZnuA1 of Candidatus Liberibacter asiaticus
2021
G Saini, V Dalal, DN Gupta, N Sharma, P Kumar, AK Sharma | Taylor and Francis
Journal: Molecular Simulation Pages: 510-525 , Volumes: 47:6 ,
Detection and molecular characterization of 'Candidatus Liberibacter asiaticus' and Citrus tristeza virus associated with citrus decline in Bhutan
2021
Ghosh DK, Kokane A, Kokane S, Tenzin J, Gubyad MG, Wangdi P, Murkute AA, Sharma AK, Gowda S | American Phytopathological Society
Journal: Phytopathology Pages: 870-881 , Volumes: 111(5) ,
A Rapid and Sensitive Reverse Transcription-Loop-Mediated Isothermal Amplification (RT-LAMP) Assay for the Detection of Indian Citrus Ringspot Virus.
2021
Kokane A, Kokane S, Warghane A, Gubyad MG, Sharma AK, Reddy KM, Ghosh DK | American Phytopathological Society
Journal: Plant Disease Pages: 1346-1355 , Volumes: 105(5) ,
Characterization of dye-decolorizing peroxidase from Bacillus subtilis
2020
Dhankhar P, Dalal V, Mahto JK, Gurjar BR, Tomar S, Sharma AK, Kumar P | Elsevier
Journal: Archives of Biochemistry and Biophysics Pages: 108590 , Volumes: 693 ,
In-silico characterization and RNA-binding protein based polyclonal antibodies production for detection of citrus tristeza virus
2020
Kokane SB, Kokane AD, Misra P, Warghane AJ, Kumar P, Gubyad MG, Sharma AK, Biswas KK, Ghosh DK | Elsevier
Journal: Molecular and Cellular Probes Pages: 101654 , Volumes: 54 ,
Characterization of heavy metal binding properties of periplasmic metal uptake protein CLas-ZnuA2
2020
Kumar P, Dalal V, Sharma N, Kokane S, Ghosh DK, Kumar P and Sharma AK | Oxford University Press, Royal Society of Chemistry
Journal: Metallomics Pages: 280-289 , Volumes: 12(2) ,
Mutation studies and structure-based identification of potential inhibitor molecules against periplasmic amino acid binding protein of Candidatus Liberibacter asiaticus CLasTcyA)
2020
Kumar P, Dalal V, Kokane A, Singh S, Lonare S, Kaur H, Ghosh DK, Kumar P and Sharma AK | Elsevier
Journal: International Journal of Biological macromolecules Pages: 1228-1238 , Volumes: 147 ,
Molecular docking and dynamic approach to virtual screen inhibitors against Esbp of Candidatus Liberibacter asiaticus
2019
Saini G, Dalal V, Savita BK, Sharma N, Kumar P, Sharma AK | Elsevier
Journal: Journal of Molecular Graphics and Modelling Pages: 329-340 , Volumes: 92 ,
Crystal Structures of a putative periplasmic cystine-binding protein from Candidatus Liberibacter asiaticus: Insights into an adapted mechanism of ligand binding.
2019
Kumar P, Kesari P, Kokane S, Ghosh DK, Kumar P, Sharma AK | Federation of European Biochemical Societies, Wiley, Wiley-Blackwell
Journal: FEBS Journal Pages: 3450-3472 , Volumes: 286 (17) ,
Development of a recombinase polymerase based isothermal amplification combined with lateral flow assay (HLB-RPA-LFA) for rapid detection of "Candidatus Liberibacter asiaticus".
2018
Ghosh DK, Kokane SB, Kokane AD, Warghane AJ, Motghare MR, Bhose S, Sharma AK, Reddy MK | Public Library of Science
Journal: PLOS ONE Pages: e0208530 , Volumes: 13(12) ,
Antimicrobial Nano-Zinc Oxide-2S Albumin protein formulation significantly inhibits growth of “Candidatus Liberibacter asiaticus” in planta
2018
Ghosh DK, Kokane S, Kumar P, Ozcan A, Warghane A, Motghare M, Santra S* and Sharma AK* | Public Library of Sciences
Journal: PLOS ONE Pages: e0204702 , Volumes: 13(10) ,
The analysis of subtle internal communications through mutation studies in periplasmic metal uptake protein CLas-ZnuA2
2018
Saini G, Sharma N, Dalal V, Warghane A, Ghosh D, Kumar P, Sharma AK | Elsevier
Journal: Journal of Structural Biology Pages: 228-239 , Volumes: 204(2) ,
Quantitative distribution of Citrus yellow mosaic badnavirus in sweet orange (Citrus sinensis) and its implication in developing disease diagnostics
2018
Motghare M, Dhar AK, Kokane A, Warghane A, Kokane S, Sharma AK, Reddy MK, Ghosh DK | Elsevier
Journal: Journal of Virological Methods Pages: 25-31 , Volumes: 259 ,
Effect of N-linked glycosylation on the activity and stability of a β-glucosidase from Putranjiva roxburghii
2018
Bibekananda Kar, Preeti Verma, Riaan den Haan and Sharma AK | Elsevier
Journal: International Journal of Biological macromolecules Pages: 490-498 , Volumes: 112 ,
Salicylaldehyde synthase activity from Venturia inaequalis elicitor-related cell culture of apple
2018
Sarkate A, Saini SS, Kumar P, Sharma AK, Sircar D | Elsevier
Journal: Journal of Plant Physiology Pages: 66-73. , Volumes: 221 ,
Characterization of AICAR transformylase/IMP cyclohydrolase (ATIC) from Staphylococcus lugdunensis
2017
Verma P, Kar B, Varshney R, Roy P, Sharma AK | Federation of European Biochemical Societies, Wiley, Wiley-Blackwell
Journal: FEBS Journal Pages: 4233-4261 , Volumes: 284 ,
Development of a simple and rapid reverse transcription loop mediated isothermal amplification (RT-LAMP) assay for sensitive detection of Citrus tristeza virus
2017
Warghane A, Misra P, Bhose S, Biswas KK, Sharma AK, Reddy MK, Ghosh DK | Elsevier
Journal: Journal of Virological Methods
Characterization of a recombinant thermostable β-glucosidase from Putranjiva roxburghii expressed Saccharomyces cerevisiae and its use for efficient biomass conversion
2017
Kar B, Verma P, den-Haan R, Sharma AK | Elsevier
Journal: Process Biochemistry Pages: 66-75 , Volumes: 63 ,
In vitro metal catalyzed oxidative stress in DAH7PS: Methionine modification leads to structure destabilization and induce amorphous aggregation.
2017
Sharma A, Kumar V, Chatrath A, Dev A, Prasad R, Sharma AK, Tomar S, Kumar P | Elsevier
Journal: International Journal of Biological macromolecules Pages: 1089-1106. , Volumes: 106 ,
A novel function for globulin in sequestering plant hormone: Crystal structure of Wrightia tinctoria 11S globulin in complex with auxin.
2017
Kumar P, Kesari P, Dhindwal S, Choudhary AK, Katiki M, Neetu, Verma A, Ambatipudi K, Tomar S, Sharma AK, Mishra G, Kumar P | Nature Portfolio
Journal: Scientific Reports Pages: 4705 , Volumes: 7(1) ,
Molecular cloning, characterization and in silico analysis of a thermostable β-glucosidase enzyme from Putranjiva roxburghii with significant activity for cellobiose
2017
Kar B, Verma P, Patel GK, Sharma AK | Elsevier
Journal: Phytochemistry Pages: 151-165 , Volumes: 140 ,
A case of neofunctionalization of a Putranjiva roxburghii PNP proteins to trypsin inhibitor by disruption of PNP-UDP domain through an in insert containing inhibitory site
2017
Verma P, Patel GK, Kar B, Sharma AK | Elsevier
Journal: Plant Science Pages: 19-30 , Volumes: 260 ,
Purification and characterization of 2S albumin from seeds of Wrightia tinctoria exhibiting antibacterial and DNase activity.
2017
Sharma A, Kumar P, Kesari P, Chaudhary N, Katiki M, Mishra M, Singh PK, Gurjar BR, Sharma AK, Tomar S, Kumar P | Bentham Science Publishers B.V.
Journal: Protein and Peptide Letters Pages: 368-378 , Volumes: 24 (4) ,
Characterization of a bacterioferritin comigratory protein family 1-Cys peroxiredoxin from Candidatus Liberibacter asiaticus
2017
Singh A, Kumar N, Tomar PP, Bhose S, Ghosh DK, Roy P, Sharma AK | Springer-Verlag Wien
Journal: Protoplasma Pages: 1675-1691. , Volumes: 254(4) ,
Structural, functional and evolutionary aspects of seed globulins
2016
Kesari P, Neetu, Sharma A, Katiki M, Kumar P, Gurjar BR, Tomar S, Sharma AK, Kumar P | Bentham Science Publishers B.V.
Journal: Protein and Peptide Letters Pages: 267-277 , Volumes: 24 (3) ,
Crystal structure analysis in Zn2+-bound state and biophysical characterization of CLas-ZnuA2
2016
Sharma N, Selvakumar P, Saini G, Warghane A, Ghosh DK, Sharma AK | Elsevier
Journal: Biochimica et Biophysica Acta (BBA) Pages: 1649-1657 , Volumes: 1864(12) ,
Loop-mediated isothermal amplification (LAMP) based method for rapid and sensitive detection of ‘Candidatus Liberibacter asiaticus’ in citrus and the psyllid vector, Diaphornia citri Kuwayama
2015
Ghosh DK, Bhose S, Warghane A, Motghare M, Sharma AK, Dhar AK, Gowda S | Springer India
Journal: Journal of Plant Biochemistry and Biotechnology Pages: 219-223 , Volumes: 25 (2) ,
Characterization and cloning of an 11S globulin with hemagglutination activity from Murraya paniculata
2015
Singh A, Selvakumar P, Saraswat A, Tomar PP, Mishra M, Singh PK, Sharma AK | Bentham Science Publishers B.V.
Journal: Protein and Peptide Letters Pages: 750-761 , Volumes: 22(8) ,
Genetic diversity of Indian populations of ‘Candidatus Liberibacter asiaticus’ based on the tandem repeat variability in a genomic locus.
2015
Ghosh DK, Bhose S, Motghare M, Warghane A, Mukherjee K, Ghosh DK Sr, Sharma AK, Ladania MS, Gowda S | The American Phytopathological Society
Journal: Phytopathology Pages: 1043-1049 , Volumes: 105(8) ,
Structural and functional evolution of chitinase-like proteins from plants.
2015
Kesari P, Patil DN, Kumar P, Tomar S, Sharma AK, Kumar P | Elsevier
Journal: Proteomics Pages: 1693-705 , Volumes: 15(10) ,
Crystal structure of a periplasmic solute binding protein in metal-free, intermediate and metal-bound states from Candidatus Liberibacter asiaticus.
2015
Sharma N, Selvakumar P, Bhose S, Ghosh DK, Kumar P, Sharma AK | Elsevier
Journal: Journal of Structural Biology Pages: 184-94 , Volumes: 189(3) ,
Purification, characterization and cloning of a 2S albumin with DNase, RNase and antifungal activities from Putranjiva roburghii
2014
Tomar PPS, Chaudhary NS, Priyadarshi P, Gahloth D, Patel GK, Selvakumar P, Kumar P and Sharma AK | Springer
Journal: Applied Biochemistry and Biotechnology Pages: 471-482. , Volumes: 174 ,
Characterization of anticancer, DNase and antifungal activity of pumpkin 2S albumin
2014
Tomar PPS, Nikhil K, Singh A, Selvakumar P, Roy P and Sharma AK | Elsevier
Journal: Biochemical and Biophysical Research Communications Pages: 349-354. , Volumes: 448 ,
Structural insights into the aggregation behavior of Murraya koenigii miraculin-like protein below pH 7.5.
2014
Selvakumar P., Sharma N., Tomar PPS, Kumar P. and Sharma AK | Wiley
Journal: Proteins Pages: 830-840 , Volumes: 82 (5) ,
Purification and physicochemical characterization of a trypsin inhibitor from Cassia Absus Linn.
2014
Patel GK, Gupta AK, Gupta A, Mishra M., Singh PK, Saxena AK and Sharma AK | Bentham Science Publishers B.V.
Journal: Protein and Peptide Letters Pages: 108-14 , Volumes: 21(2) ,
Structural investigation of a novel N-acetyl glucosamine binding chi-lectin which reveals evolutionary relationship with class III chitinases
2013
Patil D.N., Datta M., Dev A., Dhindwal S., Singh N., Dasauni P., Kundu S., Sharma A. K., Tomar S., Kumar P | Public Library of Sciences
Journal: PLOS ONE Pages: e63779 , Volumes: 23,8(5) ,
Structural basis for dual inhibitory role of tamarind Kunitz inhibitor (TKI) against factor Xa and trypsin
2012
Patil D.N., Chaudhary A., Sharma A.K., Tomar S. and Kumar P | Federation of European Biochemical Societies, Wiley, Wiley-Blackwell
Journal: FEBS Journal Pages: 4547-64 , Volumes: 279(24) ,
Purification and physicochemical characterization of a serine protease with fibrinolytic activity from latex of medicinal herb Euphorbia hirta
2012
Patel GK, Kawale AA and Sharma AK | Elsevier
Journal: Plant Physiology and Biochemistry Pages: 104-111 , Volumes: 52 ,
Characterization of a thermostable family 1 glycosyl hydrolase enzyme from Putranjiva roxburghii seeds
2012
Patel GK, Kar B, Sharma AK | Springer
Journal: Applied Biochemistry and Biotechnology Pages: 523-535 , Volumes: 166 ,
Purification and characterization of chitin deacetylase from Penicillium oxalicum SAEM-51
2012
Pareek N, Vivekanand V., Saroj S., Sharma AK, Singh RP. | Elsevier
Journal: Carbohydrate Polymers Pages: 1091-1097 , Volumes: 87(2) ,
Molecular evolution of miraculin-like protein in Kunitz super-family
2011
Selvakumar P, Gahloth D, Tomar PPS., Sharma N and Sharma AK | Springer
Journal: Journal of Molecular Evolution Pages: 369-379 , Volumes: 73(5) ,
Bioinsecticidal activity of Murraya koenigii miraculin-like protein against Helicoverpa armigera and Spodoptera litura
2011
Gahloth D, Shukla U, Birah A, Gupta GP, Kumar PA, Dhaliwal HS and Sharma AK | Wiley
Journal: Archives of Insect Biochemistry and Physiology Pages: 132-144 , Volumes: 78(3) ,
Stability of Murraya koenigii miraculin-like protein in different physicochemical conditions
2011
Patel GK, Gahloth D, Shee C, Selvakumar P, Sharma AK | Springer
Journal: Medicinal Chemistry Research Pages: 1542-1549 , Volumes: 20 ,
Identification and Partial Characterization of trypsin inhibitory activity in seed of some fruit Plants
2010
Gahloth D, Sharma AK | Springer India
Journal: Journal of Plant Biochemistry and Biotechnology Pages: 235-237 , Volumes: 19 ,
Cloning, sequence analysis and crystal structure determination of a miraculin-like protein from Murraya koenigii
2010
Gahloth D, Selvakumar P, Shee C, Kumar P, Sharma AK | Elsevier
Journal: Archives of Biochemistry and Biophysics Pages: 15–22 , Volumes: 494 ,
Crystallization and preliminary X-ray diffraction analysis of the complex of Kunitz-type tamarind trypsin inhibitor and porcine pancreatic trypsin
2009
Tomar S., Patil D.N., Datta M., Tapas S., Preeti, Chaudhary A, Sharma A. K., Tomar S, Kumar P. | IUCr
Journal: Acta Crystallographica Sect F Structural Biology Crystal Communication Pages: 1179-81 , Volumes: 65(Pt 11) ,
Purification, crystallization and preliminary crystallographic studies of a Kunitz-type proteinase inhibitor from tamarind (Tamarindus indica) seeds
2009
Patil D.N., Preeti, Chaudhry A., Sharma A. K., Tomar S., Kumar P. | IUCr
Journal: Acta Crystallographica Sect F Structural Biology Crystal Communication Pages: 736-8 , Volumes: 65(Pt 7) ,
Isolation, purification, crystallization and preliminary crystallographic studies of chitinase from tamarind (Tamarindus indica) seeds
2009
Patil D. N., Datta M, Chaudhary A, Tomar S, Sharma A. K., Kumar P. | IUCr
Journal: Acta Crystallographica Sect F Structural Biology Crystal Communication Pages: 343-5 , Volumes: 65(Pt 4) ,
Identification of a Peptide-like Compound with Antimicrobial and Trypsin Inhibitory Activity from Seeds of Bottle Gourd (Lagenaria siceraria).
2009
Shee C., Agarwal S., Deepankar G., Meena K., Sharma A. K. | Springer India
Journal: Journal of Plant Biochemistry and Biotechnology Pages: 101-104 , Volumes: 18(1) ,
Purification and characterization of a trypsin inhibitor from Putranjiva roxburghii seeds
2008
Chaudhary N. S. , Shee C., Islam A, Ahmad F., Yernool D., Kumar P., Sharma A.K. | Elsevier
Journal: Phytochemistry Pages: 2120–2126 , Volumes: 69 ,
Storage and affinity properties of Murraya koenigii trypsin inhibitor
2008
Shee C. and Sharma A. K. | Elsevier
Journal: Food Chemistry Pages: 107 , Volumes: 312–319 ,
Crystallization and preliminary X-ray diffraction studies of Murraya koenigii trypsin inhibitor
2007
Shee C., Singh T. P., Kumar P , Sharma A. K. | IUCr
Journal: Acta Crystallographica Sect F Structural Biology Crystal Communication Pages: 318-9 , Volumes: 63 (Pt 4) ,
Structure–function studies of Murraya koenigii trypsin inhibitor revealed a stable core beta sheet structure surrounded by α-helices with a possible role for α-helix in inhibitory function
2007
Shee C, Islam A, Ahmad F, Sharma A. K. | Elsevier
Journal: International Journal of Biological macromolecules Pages: 410–414 , Volumes: 41 ,
Purification and characterization of a trypsin inhibitor from the seeds of Murraya koenigii.
2007
Shee C. and Sharma A. K. | Taylor & Francis
Journal: Journal of Enzyme Inhibition and Medicinal Chemistry Pages: 115–120 , Volumes: 22 ,
Peptidic termini play a significant role in TCR recognition.
2002
Wang B. *, Sharma A.*, Maile R, Saad M., Collins E. J. and Frelinger J. A | American Association of Immunologists
Journal: Journal of Immunology Pages: 3137-45 , Volumes: 169 ,
Three-dimensional structure of a new crystal form of mare lactoferrin in 70% PEG 400 at 3.83A resolution
2001
Kumar S, Sharma A. K., Paramasivam M, Srinivasan A., Singh T. P. | NISCAIR
Journal: Indian Journal of Biochemistry and Biophysics Pages: 135-41 , Volumes: 38(3) ,
Lactoferrin – Melanin interactions and its possible implications in melanin polymerization: crystal structure of the complex formed between mare lactoferrin and melanin monomers at 2.7 A resolution
2001
Sharma A. K., Kumar S., Sharma V., Nagpal A., Singh N., Tamboli I., Mani I., Raman, G. and Singh T. P. | Wiley
Journal: Proteins Pages: 229-236 , Volumes: 45 ,
Class I MHC anchor substitutions alter the conformation of T cell receptor contacts.
2001
Sharma, A. K., Kuhns, J. J., Yan S., Freidline R., Long B., Tisch R. and Collins E. J. | American Society for Biochemistry and Molecular Biology (ASBMB)
Journal: Journal Biological Chemistry Pages: 21443-21449 , Volumes: 276 (24) ,
Class I MHC is stabilized against thermal denaturation by physiological concentrations of NaCl
2000
Batalia M. A., Kirksey T. J., Sharma A., Jiang L., Jean-Pierre Abstando, Yan S., Zhao, R., and Collins E. J. | American Chemical Society
Journal: Biochemistry Pages: 9030-9038 , Volumes: 39 (30) ,
Metal substitution in lactoferrins : the crystal structure of manganese substituted lactoferrin at 3.4 Å resolution
2000
Kumar S, Sharma A. K. and Singh T. P. | Springer
Journal: Indian Journal of Physics Pages: 143-146 , Volumes: 74 B(2) ,
Structural variability and functional convergence in lactoferrins.
1999
Karthikeyan S, Sharma S., Sharma A. K., Yadav S., Paramsivam M., Srinivasn A and Singh T. P. | Indian Academy of Sciences
Journal: Current Science Pages: 241-255 , Volumes: 77 (2) ,
Lactoferrin-metal interactions: first crystal structure of a complex of lactoferrin with a lanthanide ion (Sm3+) at 3.4 Å resolution.
1999
Sharma A. K. and Singh T. P. | IUCr
Journal: Acta Crystallographica Section D Biological Crystallography Pages: 1799-1804 , Volumes: D55 ,
Structure of oxalate-substituted diferric mare lactoferrin at 2.7 Å resolution
1999
Sharma A. K. and Singh T. P. | IUCr
Journal: Acta Crystallographica Section D Biological Crystallography Pages: 1792-1798 , Volumes: D 55 ,
Structure of apo mare lactoferrin: both N and C lobe in closed form
1999
Sharma A. K., Rajshankar, K., Yadav M. P. and Singh T. P.( | IUCr
Journal: Acta Crystallographica Section D Biological Crystallography Pages: 1152-1157 , Volumes: D 55 ,
Three-dimensional structure of diferric mare lactoferrin at 2.6 Å resolution
1999
Sharma A. K., Paramsivam M, Srinivasan A., Yadav M. P. and Singh T. P. | Elsevier
Journal: Journal of Molecular Biology Pages: 303-317 , Volumes: 289(2) ,
Structure of buffalo and mare lactoferrin: similarities, differences and flexibility.
1998
Sharma A. K., Karthikeyan S., Sharma S., Yadav S., Srinivasan A. and Singh T. P. | Springer
Journal: Advances in Experimental and Medical Biology Pages: 15-21 , Volumes: 443 ,
Purification, Crystallization and Preliminary Crystallographic Analysis of Mare Lactoferrin.
1996
Sharma A. K., Karthikeyan S., Kaur P., Yadav M. P. and Singh T. P. | IUCr
Journal: Acta Crystallographica Section D Biological Crystallography Pages: 1196-1198 , Volumes: D52 ,
Honors And Awards
MemberShips
Indian Crystallographic Association
01 Jan 2009 - Present
Member
The Biotech Research Society, India
01 Jul 2019 - Present
Member
Teaching Engagements
Teaching Engagements
Biochemistry ( BT-512 )
Autumn
Instrumental method of analysis ( BT-603 )
Spring
Biophysics ( BT-521 )
Spring
Fundamentals of Biotechnology ( BT-101 )
Autumn
Biochemistry ( BE-201 )
Spring
Microbiology and biochemistry ( BT-651 )
Autumn
Molecular separation techniques ( IBT-01 )
Autumn
Biotech Lab 1 ( BT-513 )
Autumn
Students
SuperVisions
Purification and characterization of a trypsin inhibitor from Murraya koenigii
20 Jul 2003 - 21 Oct 2007
Other Supervisors: , Scholar: Chandan Shee
Studies on some important proteins and peptides from plant and microbial sources.
01 Jan 2004 - 05 Jan 2010
Other Supervisors: , Scholar: Saurabh Agarwal
Studies on trypsin inhibitors from plants of Rutaceae family.
01 Jan 2004 - 12 Apr 2009
Other Supervisors: , Scholar: Deepankar Gahloth
Purification and characterization of a trypsin inhibitor from Putranjiva roxburghii.
01 Jan 2005 - 05 May 2009
Other Supervisors: , Scholar: Navneet S Chaudhary
Structural characterization of chitinase
01 Jan 2006 - 12 May 2009
Other Supervisors: Pravindra Kumar, Scholar: Manali Datta
Studies on glycosidae 1, protease and protease inhibitor from plants of Euphorbiaceae family
01 Jan 2007 - 20 Apr 2012
Other Supervisors: , Scholar: Girijesh K Patel
Structure-function studies on miraculin-like proteins.
01 Jan 2008 - 08 May 2013
Other Supervisors: Pravindra Kumar, Scholar: P. Selva Kumar
Studies on multifunctional low molecular weight heterodimeric proteins
01 Jan 2009 - 01 Jul 2015
Other Supervisors: , Scholar: Prabhat Pratap Singh Tomar
Studies on b-glucosidas and acid phosphatase enzymes of hydrolase family
01 Jan 2009 - 01 Aug 2015
Other Supervisors: , Scholar: Bibekanand Kar
Studies on a metal uptake protein from Candidatus Liberibacter asiaticus
01 Jan 2009 - 01 Sep 2015
Other Supervisors: , Scholar: Nidhi Sharma
Studies on peroxyredoxin antioxidant system from Candidatus Liberibacter asiaticus
01 Jan 2009 - 01 Sep 2015
Other Supervisors: Pravindra Kumar, Scholar: Anamika Singh
Studies on enzymes involved in purine nucleotide metabolism
01 Jan 2010 - 01 May 2017
Other Supervisors: , Scholar: Preeti Verma
Studies on solute binding proteins from Candidatus Liberibacter asiaticus
01 Jan 2013 - 09 Jan 2019
Other Supervisors: , Scholar: Gunjan Saini
Studies on periplasmic solute binding proteins of Candidatus Liberibacter asiaticus
01 Jan 2014 - 20 Sep 2019
Other Supervisors: , Scholar: Pranav Kumar
Investigating multifunctional properties of Pumpkin 2S Albumin and identification of its potential DNA/RNA binding site
30 Jul 2015 - 01 Mar 2022
Other Supervisors: , Scholar: Brajesh Kumar Savita
Studies of antioxidant enzyme peroxyredoxins from Candidatus Liberibacter asiaticus and its host Citrus sinensis
02 Jan 2016 - 20 Dec 2022
Other Supervisors: , Scholar: Deena Nath Gupta
Miscellaneous
Events
Hands on Training on Modern Techniques in Biotechnology (Nano/Structural Biotechnology)
07 Jan 2013 - 12 Jan 2013
Uttarakhand State Biotechnology Department
48th National Seminar on Crystallography
25 Nov 2021 - 27 Nov 2021
Indo-US International Conference on Recent Advances in Structural Biology and drug discovery
09 Oct 2014 - 11 Oct 2014
International Conference on ‘ Molecular Signaling :Recent Trends in Biomedical Transnatinal Research
17 Dec 2014 - 19 Dec 2014