1. Singh V, Bhutkar M, Choudhary S., Nehul S., Kumar R, Singla J., Kumar P., Tomar S*. 2024 Enhancing affinity of neutralizing SARS-CoV-2 nanobody through facile structure-guided mutations in CDRs. doi: https://doi.org/10.1101/2024.05.13.593833. (Article in preprint)
2. Nehul, S., Rani, R., Panda, P. K., Kumar, P., Tomar, S*. (2024). Repurposing efavirenz, the HIV antiretroviral drug for Chikungunya virus infection. https://doi.org/10.1101/2023.09.29.560149 (Article in preprint)
3. Singh VA, Nehul S, Kumar CS, Banerjee M, Kumar P, Sharma G, Tomar S*. 2023 Chimeric chikungunya virus-like particles with surface exposed SARS-CoV-2 RBD elicits potent immunogenic responses in mice. bioRxiv. Jan 29:2023-01. https://doi.org/10.1101/2023.01.29.526074 (Article in preprint)
4. Rani, R., Nehul, S., Choudhary, S., Upadhyay, A., Sharma, G.K., Kumar, P. and Tomar, S*., 2023. Revealing and evaluation of antivirals targeting multiple druggable sites of RdRp complex in SARS- CoV-2. bioRxiv, pp.2023-07. DOI:10.1101/2023.07.24.550324 (Article in preprint)
5. Bhutkar, M., Rani, R., Kothiala, A., Mahajan, S., Waghmode, B., Kumar, R., Singh, V., Sircar, D., Kumar, P. and Tomar, S*. 2022. Elucidation of the antiviral mechanism of natural therapeutic molecules Herbacetin and Caffeic acid phenethyl ester against Chikungunya and Dengue virus. bioRxiv. doi: https://doi.org/10.1101/2022.05.31.494145
6. Mahajan, S., Kumar, R., Singh, A., Pareek, A., Long, S., McInerney, G., Tomar, S*., 2022. Targeting host protein G3BP1 for the discovery of novel antiviral inhibitors against the Chikungunya virus.bioRxiv. doi: https://doi.org/10.1101/2022.11.11.516135
7. Choudhary, S., Nehul, S., Kumar, K.A., Sharma, S., Rani, R., Saha, A., Sharma, G.K., Tomar, S*. and Kumar, P., 2022. Crystal structure and activity profiling of deubiquitinating inhibitors-bound to SARS-CoV-2 papain like protease revealed new allosteric sites for antiviral therapies. bioRxiv. doi: https://doi.org/10.1101/2022.11.11.516107
8. Singh, V.A., Kumar, C.S., Khare, B., Kuhn, R.J., Banerjee, M. and Tomar, S*., 2023. Surface decorated reporter-tagged chikungunya virus-like particles for clinical diagnostics and identification of virus entry inhibitors. Virology, 578, pp.92-102 https://doi.org/10.1016/j.virol.2022.11.012
9. Bhatia, P., Singh, V.A., Rani, R., Nath, M. and Tomar, S*., 2023. Cellular uptake of metal oxide-based nanocomposites and targeting of chikungunya virus replication protein nsP3. Journal of Trace Elements in Medicine and Biology, p.127176, DOI: 10.1016/j.jtemb.2023.127176
10. de Souza, B.G., Choudhary, S., Vilela, G.G., Passos, G.F.S., Costa, C.A.C.B., de Freitas, J.D., Coelho, G.L., de Andrade Brandão, J., Anderson, L., Bassi, Ê.J. and de Araújo-Júnior, J.X., Tomar, S., Silva Junior., EF., 2023. Design, synthesis, antiviral evaluation, and In silico studies of acrylamides targeting nsP2 from Chikungunya virus. European Journal of Medicinal Chemistry, p.115572.https://doi.org/10.1016/j.ejmech.2023.115572
11. Lonare, S., Sharma, M., Dalal, V., Gubyad, M., Kumar, P., Gupta, D.N., Pareek, A., Tomar, S., Ghosh, D.K., Kumar, P. and Sharma, A.K., 2023. Identification and evaluation of potential inhibitor molecules against TcyA from Candidatus Liberibacter asiaticus. Journal of Structural Biology, 215(3), p.107992. DOI: 10.1016/j.jsb.2023.107992
12. Neetu, N., Mahto, J.K., Sharma, M., Katiki, M., Dhaka, P., Roy, P., Tomar, S., Narayan, A., Yernool, D. and Kumar, P., 2023. Sulisobenzone is a potent inhibitor of the global transcription factor Cra. Journal of Structural Biology, 215(4), p.108034. DOI: 10.1016/j.jsb.2023.108034
13. Choudhary S, Nehul S, Singh A, Panda PK, Kumar P, Sharma GK, Tomar S*. 2023 Unraveling antiviral efficacy of multifunctional immunomodulatory triterpenoids against SARS‐COV‐2 targeting main protease and papain‐like protease. IUBMB life. DOI: 10.1002/iub.2793
14. Dhaka, P., Singh, A., Choudhary, S., Peddinti, R.K., Kumar, P., Sharma, G.K. and Tomar, S*., 2023. Mechanistic and thermodynamic characterization of antiviral inhibitors targeting nucleocapsid N-terminal domain of SARS-CoV-2. Archives of Biochemistry and Biophysics, p.109820. DOI: 10.1016/j.abb.2023.109820
15. Gupta, D.N., Lonare, S., Rani, R., Singh, A., Ghosh, D.K., Tomar, S., and Sharma, A.K., 2023. Comparative Analysis of Inhibitor Binding to Peroxiredoxins from Candidatus Liberibacter asiaticus and Its Host Citrus sinensis. Applied Biochemistry and Biotechnology. DOI: 10.1007/s12010-023-04798-y
16. Pareek, A., Kumar, R., Mudgal, R., Neetu, N., Sharma, M., Kumar, P. and Tomar, S.* (2022), Alphavirus antivirals targeting RNA-dependent RNA polymerase domain of nsP4 divulged using surface plasmon resonance. The FEBS Journal. https://doi.org/10.1111/febs.16397
17. Dubey, A., Choudhary, S., Kumar, P. Tomar S*. Emerging SARS-CoV-2 Variants: Genetic Variability and Clinical Implications. Current Microbiology 79, 20 (2022).https://doi.org/10.1007/s00284-021-02724-1
18. Gupta, D.N., Rani, R., Kokane, A.D., Ghosh, D.K., Tomar, S. and Sharma, A.K., 2022. Characterization of a cytoplasmic 2-Cys peroxiredoxin from Citrus sinensis and its potential role in protection from oxidative damage and wound healing. International Journal of Biological Macromolecules, 209, pp.1088-1099. https://doi.org/10.1016/j.ijbiomac.2022.04.086
19. Bhutkar, M., Singh, V., Dhaka, P., and Tomar S*. Virus-host protein-protein interactions as molecular drug targets for arboviral infections. Frontiers in Virology, p.70, (2022). https://doi.org/10.3389/fviro.2022.959586
20. Rani, R., Long, S., Pareek, A., Dhaka, P., Singh, A., Kumar, P., McInerney, G. and Tomar, S*., 2022. Multi-target direct-acting SARS-CoV-2 antivirals against the nucleotide-binding pockets of virus-specific proteins. Virology, 577, pp.1-15.Doi: https://doi.org/10.1016/j.virol.2022.08.008
21. Kumar, K.A., Sharma, M., Dalal, V., Singh, V., Tomar, S. and Kumar, P., 2021. Multifunctional Inhibitors of SARS CoV2 by MM/PBSA, Essential dynamics, and Molecular dynamic investigations. Journal of Molecular Graphics and Modelling, p.107969. https://doi.org/10.1016/j.jmgm.2021.107969
22. Choudhary, S., Neetu., Singh, VA., Kumar, P., Chaudhary, M., Tomar, S*., 2021. Chikungunya virus titration, detection and diagnosis using N-Acetylglucosamine (GlcNAc) specific lectin based virus capture assay. Virus Research. p.198493. https://doi.org/10.1016/j.virusres.2021.198493
23. Kumar, R., Nehul, S., Singh, A. and Tomar, S*., 2021. Identification and evaluation of antiviral potential of thymoquinone, a natural compound targeting Chikungunya virus capsid protein. Virology. 561:36-46. doi: 10.1016/j.virol.2021.05.013
24. Malik, Y.S., Ansari, M.I., Kattoor, J.J., Kaushik, R., Sircar, S., Subbaiyan, A., Tiwari, R., Dhama, K., Ghosh, S., Tomar, S. and Zhang, K.Y., 2021. Evolutionary and codon usage preference insights into spike glycoprotein of SARS-CoV-2. Briefings in bioinformatics, 22(2), pp.1006-1022 https://doi.org/10.1093/bib/bbaa383
25. Sharma, M., Mahto, J.K., Dhaka, P., Neetu, N., Tomar, S. and Kumar, P., 2021. MD simulation and MM/PBSA identifies phytochemicals as bifunctional inhibitors of SARS-CoV-2. Journal of Biomolecular Structure and Dynamics, pp.1-14. https://doi.org/10.1080/07391102.2021.1969285
26. Mahajan, S., Choudhary, S., Kumar, P. and Tomar, S., 2021. Antiviral strategies targeting host factors and mechanisms obliging+ ssRNA viral pathogens. Bioorganic & Medicinal Chemistry, 46, p.116356https://doi.org/10.1016/j.bmc.2021.116356
27. Savita, B.K., Dalal, V., Choudhary, S., Gupta, D.N., Das, N., Tomar, S., Kumar, P., Roy, P. and Sharma, A.K., 2021. Characterization of recombinant pumpkin 2S albumin and mutation studies to unravel potential DNA/RNA binding site. Biochemical and Biophysical Research Communications, 580, pp.28-34. https://doi.org/10.1016/j.bbrc.2021.09.076
28. Neetu, N., Katiki, M., Mahto, J.K., Sharma, M., Narayanan, A., Maity, S., Tomar, S., Ambatipudi, K., Sharma, A.K., Yernool, D. and Kumar, P., 2021. Deciphering the enigma of missing DNA binding domain of LacI family transcription factors. Archives of Biochemistry and Biophysics, p.109060. https://doi.org/10.1016/j.abb.2021.109060
29. Mahto, J.K., Neetu, N., Waghmode, B., Kuatsjah, E., Sharma, M., Sircar, D., Sharma, A.K., Tomar, S., Eltis, L.D. and Kumar, P., 2021. Molecular insights into substrate recognition and catalysis by phthalate dioxygenase from Comamonas testosteroni. Journal of Biological Chemistry, p.101416. DOI:https://doi.org/10.1016/j.jbc.2021.101416
30. Mudgal, R., Bharadwaj, C., Dubey, A., Choudhary, S., Nagarajan, P., Aggarwal, M., Ratra, Y., Basak, S. and Tomar, S.*, 2021. Selective estrogen receptor modulators limit alphavirus infection by targeting the viral capping enzyme nsP1. Antimicrobial Agents and Chemotherapy, pp.AAC-01943.DOI: https://doi.org/10.1128/aac.01943-21
31. Neetu, N., Katiki, M., Dev, A., Gaur, S., Tomar, S. and Kumar, P., 2020. Structural and biochemical analyses reveal that chlorogenic acid inhibits the shikimate pathway. Journal of Bacteriology, 202(18), pp.e00248-20.Doi: 10.1128/JB.00248-20
32. Mudgal, R., Mahajan, S. and Tomar, S*., 2020. Inhibition of Chikungunya virus by an adenosine analog targeting the SAM‐dependent nsP1 methyltransferase. FEBS letters, 594(4), pp.678-694.https://doi.org/10.1002/1873-3468.13642
33. Choudhary, S., Kumar, R., Dalal, U., Tomar, S*. and Reddy, S.N., 2020. Green synthesis of nanometal impregnated biomass–antiviral potential. Materials Science and Engineering: C, 112, page no.110934https://doi.org/10.1016/j.msec.2020.110934
34. Fatma, B., Kumar, R., Singh, V.A., Nehul, S., Sharma, R., Kesari, P., Kuhn, R.J. and Tomar, S*., 2020. Alphavirus capsid protease inhibitors as potential antiviral agents for Chikungunya infection. Antiviral Research, 179, page no.104808.https://doi.org/10.1016/j.antiviral.2020.104808
35. Rani R, Singh A, Pareek A, Tomar S*. 2020: In Silico Guided Drug Repurposing to Combat SARS-CoV-2 by Targeting Mpro, the Key Virus Specific Protease. Chemrxiv (Article in Preprint).doi:10.26434/chemrxiv.12030345.v1
36. Choudhary, S., Malik, Y.S. and Tomar, S*., 2020. Identification of SARS-CoV-2 cell entry inhibitors by drug repurposing using in silico structure-based virtual screening approach. Frontiers in Immunology, 11, page no.1664.https://doi.org/10.3389/fimmu.2020.01664
37. Dhankhar, P., Dalal, V., Singh, V., Tomar, S*. & Kumar, P., 2020. Computational guided identification of novel potent inhibitors of N-terminal domain of nucleocapsid protein of severe acute respiratory syndrome coronavirus 2. Journal of Biomolecular Structure and Dynamics, pp.1-16. https://doi.org/10.1080/07391102.2020.1852968
38. Mudgal R, Nehul S, Tomar S* (2020) Prospects for mucosal vaccine: shutting the door on SARS-CoV-2.Human Vaccines & Immunotherapeutics.Dec 1;16(12):2921-2931. Epub 2020 Sep 15. doi: 10.1080/21645515.2020.1805992.
39. Dhankhar P, Dalal V, Mahto JK, Gurjar BR, Tomar S, Sharma AK, Kumar P. Characterization of dye-decolorizing peroxidase from Bacillus subtilis. Archives of Biochemistry and Biophysics. 2020 Oct 30;693:108590. Epub 2020 Sep 21. doi: 10.1016/j.abb.2020.108590.
40. Bais S., Ratra Y., Khan N., Pandey R., Kushawaha P.,Tomar S., Medigeshi G., Singh A., Basak S*. (2019) Cytopathic RNA viruses require pro-survival RelA NF-kB function for their propagation. Journal of Virology. 93(14), pp.e00081-19. doi: 10.1128/JVI.00081-19
41. Chandra R, Singh V, Tomar S*, Nath M*. Multi-core-shell composite SnO2NPs@ZIF-8: potential antiviral agent and effective photocatalyst for waste-water treatment. (2019) Environmental Science and Pollution Research Int. 26(23):23346-23358. doi: 10.1007/s11356-019-05646-5.
42. Kaur R., Neetu N., Mudgal R., Jose J., Kumar P., Tomar S. (2018). Glycan-dependent chikungunya viral infection divulged by antiviral activity of NAG specific chi-like lectin. Virology 526:91-98 doi:10.1016/j.virol.2018.10.009
43. Malik A., Dalal V., Ankri S. and Tomar S*. 2019 Structural insights into the arginase enzyme of E. histolytica and identification of novel non-amino acid based inhibitors by structure-based drug repositioning approach. The FEBS journal 286(20):4135-4155. doi: 10.1111/febs.14960
44. Dalal V, Kumar P, Rakhaminov G, Qamar A, Fan X, Hunter H, Tomar S, Golemi-Kotra D, Kumar P. 2019 Repurposing an Ancient Protein Core Structure: Structural Studies on FmtA, a Novel Esterase of Staphylococcus aureus. Journal of Molecular Biology. ;431(17):3107-3123. doi:10.1016/j.jmb.2019.06.019.
45. Puranik N, Rani R., Singh V., Tomar S. *, Putambkar H.M. and Srivastava P*. (2019) Evaluation of the antiviral potential of halogenated dihydrorugosaflavonoids and molecular modelling with nsP3 protein of Chikungunya virus (CHIKV). ACS Omega. 4, (23), 20335–20345 https://doi.org/10.1021/acsomega.9b0290
46. Sharma A., Kumar V., Chatrath A., Dev A., Prasad R., Sharma, A. K., Tomar S., Kumar P. (2018). In vitro metal catalyzed oxidative stress in DAH7PS: Methionine modification leads to structure destabilization and induce amorphous aggregation. International Journal of Biological Macromolecules 106:1089-1106.DOI: 10.1016/j.ijbiomac.2017.08.105
47. Sharma R., Kesari P., Kumar P., Tomar S*. (2018) Structure-function insights into chikungunya virus capsid protein: Small molecules targeting capsid hydrophobic pocket. Virology. 515:223-234. DOI: 10.1016/j.virol.2017.12.020
48. Singh H., Mudgal R., Narwal M., Kaur R., Singh V. A., Malik A., Chaudhary M., Tomar S*. (2018) Chikungunya virus inhibition by peptidomimetic inhibitors targeting virus-specific cysteine protease. Biochimie. 149:51-61. DOI: 10.1016/j.biochi.2018.04.004
49. Malik A., Singh H., Pareek A., Tomar S*. (2018) Biochemical and biophysical insights into the metal binding spectrum and bioactivity of arginase of Entamoeba histolytica. Metallomics. 25;10(4):623-638. DOI: 10.1039/c8mt00002f
50. Narwal M., Singh H., Pratap S., Malik A., Kuhn R. J., Kumar P., Tomar S*. (2018) Crystal structure of chikungunya virus nsP2 cysteine protease reveals a putative flexible loop blocking its active site. International Journal of Biological Macromolecules. 116:451- 62. DOI: 10.1016/j.ijbiomac.2018.05.007
51. Kaur R., Mudgal R., Narwal M., Tomar S*. (2018) Development of an ELISA assay for screening inhibitors against divalent metal ion dependent alphavirus capping enzyme. Virus Research. pii: S0168-1702(18)30028-5. DOI: 10.1016/j.virusres.2018.06.013
52. Saha A., Acharya B. N., Priya R., Tripathi N. K., Shrivastava A., Rao M. K., Kesari P., Narwal M., Tomar S., Bhagyawant S. S., Parida M., Dash P. K. (2018) Development of nsP2 protease based cell free high throughput screening assay for evaluation of inhibitors against emerging Chikungunya virus. Scientific Reports. 8:10831.DOI: 10.1038/s41598-018-29024-2
53. Aggarwal M., Kaur R., Saha A., Mudgal R., Yadav R., Dash P. K., Parida M., Kumar P., Tomar S. (2017). Evaluation of antiviral activity of piperazine against Chikungunya virus targeting hydrophobic pocket of alphavirus capsid protein. Antiviral Research. 146 (102-111). DOI: 10.1016/j.antiviral.2017.08.015
54. Pratap S., Dev A., Kumar V., Yadav R., Narwal M., Tomar S., Kumar P. (2017) Structure of Chorismate Mutase-like Domain of DAHPS from Bacillus subtilis Complexed with Novel Inhibitor Reveals Conformational Plasticity of Active Site. Scientific Reports. 25;7(1):6364.DOI: 10.1038/s41598-017-06578-1
55. Kumar P., Kesari P., Dhindwal S., Choudhary A. K., Katiki M., Neetu, Verma A., Ambatipudi K., Tomar S., Sharma A. K., Mishra G., Kumar P. (2017) A novel function for globulin in sequestering plant hormone: Crystal structure of Wrightia tinctoria 11S globulin in complex with auxin. Scientific Reports. 5;7(1):4705. DOI: 10.1038/s41598-017-04518-7
56. Sharma A., Kumar P., Kesari P., Katiki M., Mishra M., Singh P. K., Gurjar B. R., Sharma A. K., Tomar S., Kumar P. (2017) Purification and Characterization of 2S Albumin from Seeds of Wrightia tinctoria Exhibiting Antibacterial and DNase Activity. Protein and Peptide Letters. 1;24(4):368-78. DOI: 10.2174/0929866524666170126144936
57. Kesari P., Sharma A., Katiki M. Kumar P., Gurjar B. R., Tomar S., Sharma A. K., Kumar P. (2017) Structural, Functional and Evolutionary Aspects of Seed Globulins. Protein peptide letters 1;24(3):267-77. DOI: 10.2174/0929866523666161220112641
58. Dhindwal S., Kesari P., Singh H., Kumar P., Tomar S. (2016) Conformer and Pharmacophore Based Identification of Peptidomimetic Inhibitors of Chikungunya Virus nsP2 Protease. Journal of Biomolecular Structure and Dynamics 2:1-18. DOI: 10.1080/07391102.2016.1261046
59. Sharma R., Fatma B., Saha A., Bajpai S., Sistla S., Dash P. K., Parida M., Kumar P., Tomar S. (2016) Inhibition of chikungunya virus by picolinate that targets viral capsid protein, Virology, 265–276. DOI: 10.1016/j.virol.2016.08.029
60. Batra M., Sharma R., Malik A., Dhindwal S., Kumar P., Tomar S. (2016) Crystal structure of pentapeptide-independent chemotaxis receptor methyltransferase (CheR) reveals idiosyncratic structural determinants for receptor recognition. Journal of Structural Biology 196(3):364-374. DOI: 10.1016/j.jsb.2016.08.005
61. Aggarwal M., Sharma R., Kumar P., Parida M., Tomar S. (2015) Kinetic characterization of trans-proteolytic activity of Chikungunya virus capsid protease and development of a FRET-based HTS assay. Scientific. Reports. 5:14753. https://doi.org/10.1038/srep14753
62. Batra M., Sharma R., Chandra V., Aggarwal M., Agarwal U., Gupta P, Singh R. P., Tomar S. (2015) In silico and proteomic analysis of protein methyltransferase CheR from Bacillus subtilis. International Journal of Biological Macromolecules. 77:168-80. DOI: 10.1016/j.ijbiomac.2015.03.023
63. Kesari P., Patil D. N., Kumar P., Tomar S., Sharma A. K., Kumar P. (2015) Structural and functional evolution of chitinase-like-proteins from plants. Proteomics 15(10):1693-705. DOI: 10.1002/pmic.201400421
64. Dhindwal S., Priyadarshini P., Patil D. N., Tapas S., Kumar P., Tomar S., Kumar P. (2015) Ligand-bound structures of 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase from Moraxella catarrhalis reveal a water channel connecting to the active site for the second step of catalysis. Acta Crystallographica Section D 71(Pt 2):239-55. DOI: 10.1107/S1399004714025218
65. Aggarwal M., Dhindhwal S., Kumar P., Kuhn R. J., Tomar S. (2014) Trans-protease activity and structural insights into the active form of the alphavirus capsid protease. Journal of Virology., 88(21):12242-53. DOI: 10.1128/JVI.01692-14
66. Patil D. N., Datta M., Dev A., Dhindwal S., Singh N., Dasauni P., Kundu S., Sharma A. K., Tomar S., Kumar P. (2013) Structural investigation of a novel N-acetyl glucosamine binding chi-lectin which reveals evolutionary relationship with class III chitinases. PLoS One. 8 (5):e63779. doi: 10.1371/journal.pone.0063779.
67. Kumar P., Patil D. N., Chaudhary A., Tomar S., Yernool D., Singh N., Dasauni P., Kundu S., Kumar P. (2013) Purification and Biophysical Characterization of an 11S Globulin from Wrightia tinctoria exhibiting Hemagglutinating Activity. Protein Peptide Letters 20(5):499-509.DOI: 10.2174/0929866511320050002
68. Preeti; Tapas S., Kumar P., Madhubala R., Tomar S. (2013) Structural Insight into DFMO Resistant Ornithine Decarboxylase from Entamoeba histolytica: An Inkling to Adaptive Evolution. PLoS ONE 8(1):e53397:10.1371/journal.pone.0053397. Epub 2013 Jan 11. DOI: 10.1371/journal.pone.0053397
69. Aggarwal M., Tapas S., Preeti, Siwach A., Kumar P., Kuhn R. J., Tomar S. (2012) Crystal structure of Aura virus capsid protease and its complex with dioxane: new insights into capsid-glycoprotein molecular contacts. PLoS ONE 7(12):e51288.
70. Pratap S., Narwal M., Dev A., Dhindwal S., Tomar S., Kumar P. (2012) Crimean-Congo Hemorrhagic Fever Virus: Strategies to Combat with an Emerging Threat to Human. Current Bioinformatics, 7(4), 467-477. https://doi.org/10.1371/journal.pone.0051288
71. Patil D. N., Chaudhary A., Sharma A. K., Tomar S., Kumar P. (2012) Structural basis for dual inhibitory role of tamarind Kunitz inhibitor (TKI) against factor Xa and trypsin. FEBS Journal. Dec;279(24):4547-64. DOI: 10.1111/febs.12042
72. Preeti, Tapas S., Kumar P., Madhubala R., Tomar S. (2012) Biochemical, mutational and in silico structural evidence for a functional dimeric form of the ornithine decarboxylase from Entamoeba histolytica. PLoS Neglected Tropical Diseases 6(2):e1559. DOI: 10.1371/journal.pntd.0001559
73. Aggarwal M., Dhindwal S., Pratap S., Kuhn R. J., Kumar P., Tomar S. (2011) Crystallization, high-resolution data collection and preliminary crystallographic analysis of Aura virus capsid protease and its complex with dioxane. Acta Crystallographica Section F 1;67 (Pt 11):1394-8. DOI: 10.1107/S174430911103404X
74. Tomar S., Narwal M., Harms E., Smith J. L., Kuhn R .J. (2011) Heterologous production, purification and characterization of enzymatically active Sindbis virus nonstructural protein nsP1. Protein Expression and Purification 79(2):277-84. DOI: 10.1016/j.pep.2011.05.022
75. Dhindwal S., Patil D. N., Mohammadi M., Sylvestre M., Tomar S., Kumar P. (2011) Biochemical studies and ligand bound of biphenyl dehydrogenase from Pandoraea pnomenusa strain B-356 reveal a basis for broad specificity of the enzyme. Journal of Biological Chemistry. 286(42):37011-22. DOI: 10.1074/jbc.M111.291013
76. Tapas S., Patel G. K., Dhindwal S., Tomar S. (2010) In silico sequence analysis and homology modeling of DAHP synthase from Pseudomonas fragi. Journal of Molecular Modeling.17(CCP4), 621-31. DOI: 10.1007/s00894-010-0764-y
77. Sakshi, Patil D. N., Tomar S., Sylvestre M., Kumar P. (2010) Expression, purification, crystallization and preliminary crystallographic studies of cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase from Pandoraea pnomenusa B-356. Acta Crystallographica Section F 66, 1517-1520. doi: 10.1107/S1744309110036894
78. Datta M. and Tomar S. (2010) Molecular cloning and structural characterization of catalytic domain of class III chitinase Tamarindus indica. Int. J. Life Sci. and Tech. 3(2) 16-28.
79. Patil D. N., Preeti, Chaudhry A., Sharma A. K., Kumar P.*, Tomar S.* (2009) Purification, crystallization and preliminary crystallographic studies of a Kunitz-type proteinase inhibitor from tamarind (Tamarindus indica) seeds. Acta Crystallographica Section F. 65: 736-738. DOI: 10.1107/S1744309109023495
80. Patil D. N., Preeti, Chaudhry A., Tomar S., Sharma A. K., Kumar P. (2009) Isolation, purification, crystallization and preliminary crystallographic studies of chitinase from tamarind (Tamarindus indica) seeds. Acta Crystallographica Section F. 65, 343-345. DOI: 10.1107/S1744309109006472
81. Tomar S., Patil D. N., Datta M., Tapas S., Preeti, Sharma A. K., Tomar S.*, Kumar P.* (2009) Crystallization and preliminary X-ray diffraction analysis of the complex of Kunitz-type tamarind trypsin inhibitor and porcine pancreatic trypsin. Acta Crystallographica Section F 65: 1179-1181. doi: 10.1107/S1744309109041694
82. Tomar S., Hardy R. W., Smith J. L., Kuhn R. J. (2006). Catalytic core of alphavirus nonstructural protein, nsP4 possesses terminal adenylyl transferase activity. Journal of Virology 80(20): 9962-9. DOI: 10.1128/JVI.01067-06
83. Bilgrami S., Tomar S., Yadav S., Kaur P., Kumar J., Jabeen T., Sharma S., Singh T. P. (2004) Crystal structure of schistatin, disintegrin homodimer from saw-scaled viper (Echis carinatus) at 2.5 A resolution. Journal of Molecular Biology 341(3):829-37. DOI: 10.1016/j.jmb.2004.06.048
84. Tomar S., Yadav S., Chandra V., Kumar P., Singh T. P. (2001) Purification, crystallization and preliminary X-ray diffraction studies of disintegrin (schistatin) from saw-scaled viper (Echis carinatus). Acta Crystallographica Section D. 57:1669-70. DOI: 10.1107/s0907444901012082
Patents granted and filed
Patents Granted
- Tomar S., Kumar P., Kaur R., Chaudhary N., Singh VA., An antiviral composition of tamarind chi-like lectin and uses thereof. Indian patent, Application no. 201811019298 on May 23rd 2018.Patent granted (Patent No. 413264)
- Tomar S., Kumar P., Kaur R., Chaudhary N., Singh VA., An antiviral composition of tamarind chi-like lectin and uses thereof. Indian patent, Application no. 201811019298 on May 23rd 2018 Patent granted (Patent No. 413264)
- Tomar S., Kumar P., Singh H., Mudgal R. Chikungunya virus protease inhibitors and uses thereof. Indian patent, Application no. 201811022065 on June 13th 2018 Patent granted (Patent No. 536426)
Patents filed
- Kumar N., Tomar S., Saini R., Singh A., Kumar M., Bhatia S., Sanyal A., Chimeric neuraminidase tetramers as universal influenza vaccine candidates. (2023) (Indian Patent Application No. 202411006826, February 23rd, 2024)
- Tomar S. Kumar P., Singh VA., Nehul S.K., Sharma G. Alphavirus virus-like particles (VLP) containing immunogenic proteins of pathogens and its uses thereof. (Indian Patent Application No. 202311004737, January 24th, 2023)
- Tomar S., Kumar P., Singh V.A., Nanoluciferse reporter tagged virus-like particles, a method for producing the same, and applications thereof (Indian patent application, 202211066289., 18th November 2022)
- Tomar S., Khoba Prafful., Bhutkar M., A portable ultraviolet sterilization and disinfection device. Indian Patent, Provisional Application no. 202111046071 dated. 09/10/2021
- Tomar,S., Kumar, P., Sircar, D., Kumar, R., Singh, V.A. A prophylactic and therapeutic antiviral composition and method thereof. Indian Patent, Application no. 202011023131, Dated 2nd June 2020.
- Tomar S., Mudgal R, and Dubey A., An antiviral composition against alphaviruses. Indian Patent Application no 201911049130, Dated 29th Nov, 2019
- Tomar S., Kumar P., Neetu, Singh VA. and Choudhary S. Chikungunya virus titration and detection kit. Indian patent application no. 201911035044 on 30th Aug, 2019
- Tomar S., Kumar P. and Kaur R.; “A highly sensitive nsp1 enzyme assay and kit for determining inhibitors of alphavirus/chikungunya virus.” PCT application no. PCT/IB2018/051760 (16th March 2018).
Books Authored
- Singh A, Dhaka P, Kumar P, Tomar S, Singla J. 2024. Book Chapter 2: Bioinformatics databases and tools available for the development of antiviral drugs. Nature Springer Singapore Press. DOI:10.1007/978-981-99-9195-2_2
- Rani R, Bhutkar M, Tomar S. 2023. Chapter 4: Therapeutic antiviral potential of flavonoids. Apple Academic Press (AAP) https://doi.org/10.1201/9781003412441
- Tomar, S., Mahajan, S. and Kumar, R., 2020. Chapter 19: Advances in structure-assisted antiviral discovery for animal viral diseases. In Genomics and biotechnological advances in veterinary, poultry, and fisheries (pp. 435-468). Academic Press.
- Tomar S. Kaur R., Singh VA (2019) Chapter 2: Structure-Function Relationship of Negative- Stranded Viral RNA Polymerases: Prospectives for Antiviral Therapy. In: Gupta, S.P. (Ed.), Viral Polymerases: Structures, Functions, and Roles in Antiviral Drug Targets. Academic Press, Elsevier 2019, Pages 43-67; https://doi.org/10.1016/B978-0-12-815422-9.00002-4
- Tomar S. Mudgal R and Pareek A. (2019) Chapter 3: RNA-Dependent RNA Polymerase of Alphaviruses: A Potential Target for the Design of Drugs Against Alphaviruses In: Gupta, SP. (Ed.), Viral Polymerases: Structures, Functions, and Roles in Antiviral Drug Targets. Acad. Press Elsevier https://doi.org/10.1016/B978-0-12-815422-9.00003-6.
- Kesari, P., Neetu, Tomar,S., Kumar, P., (2017). Polychlorinated Biphenyls Bioremediation. In: Environmental Pollution: Biodegradation and Bioremediation. Series Studium press LLC USA., pp. 258-280
- Tomar, S., Aggarwal, M. (2017). Structure and function of alphavirus proteases. In: Gupta, S.P. (Ed.), Viral Proteases and Their Inhibitors. Academic Press. Elsevier Inc., pp. 105-136
- Tomar, S., Mudgal, R., Fatima B. (2017). Flavivirus Protease: An antiviral target. In: Gupta, S.P. (Ed.), Viral Proteases and Their Inhibitors. Academic Press. Elsevier Inc., pp. 137-161.