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Ranjana Pathania
Professor
ranjana.pathania[at]bt.iitr.ac.in
01332-285324
Research Interests

Biosketch
Educational Details
Professional Background

Research
Projects
Publications
Patents
Books
Collaborations

Honours and Awards
Honors
Memberships

Teaching Engagements
Teaching Engagements

Students
Supervisions
Associate Scholars

Miscellaneous
Events
Visits
Administrative Positions
Miscellaneous
Research Interests
Antibiotic Resistance, Bacterial Pathogenesis, Small RNA in Acinetobacter baumannii, Chemical genetic approaches for antibacterial drug discovery
BioSketch
Educational Details
GNDU, Amritsar, Punjab
1995
B.Sc (Hon.), Microbiology
GNDU, Amritsar, Punjab
1997
M.Sc, Biotechnology
CSIR-IMTECH
2004
Ph.D, Biotechnology & Molecular Microbiology
Professional Background
Professor
17 Dec 2019 - Present
Department of Biosciences and Bioengineering, Indian Institute of Technology Roorkee
Associate Professor
02 Apr 2014 - 16 Dec 2019
Department of Biosciences and Bioengineering, IIT Roorkee
Assistant Professor
25 Oct 2007 - 01 Apr 2014
Department of Biosciences and Bioengineering, IIT Roorkee
Postdoctoral Research Fellow
03 Nov 2003 - 23 Oct 2007
Department of Biochemistry and Biomedical Sciences, McMaster University, ON, Canada
Postdoctoral Research Fellow
03 May 2003 - 02 Nov 2003
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
Research
Projects
TOPIC START DATE FIELD DESCRIPTION FINANCIAL OUTLAY FUNDING AGENCY OTHER OFFICERS
Deciphering the role of small RNAs in Acinetobacter baumannii physiology and pathobiology 01 Jan 2022 (RNA biology) 4.44 Cr DBT/Wellcome Trust India Alliance
Elucidating the Mechanism of Small RNAs and RNA Chaperone Hfq in Antibiotic Tolerance and Virulence in Acinetobacter baumannii 01 Sep 2021 (Molecular microbiology, RNA-Protein interactions) 87.7152 lakhs DBT
Evaluation of genetically attenuated whole cell vaccines against MDR Acinetobacter baumannii 23 Feb 2020 ( Whole cell vaccine development) 50 Lakhs MHRD-STARS
Inhibition of clinically relevant carbapenemase 01 Jan 2018 (Antibiotic Resistance) Indo-Norway project jointly funded by ICMR-RCN 5.34 Cr ICMR-RCN (Indo-Norway)
Chemical genetic approaches for the discovery of novel antibacterials against antibiotic Gram-negative pathogens 01 Jan 2018 Chemical genetic 64.73 Lakhs SERB
Chemical genetic approach for discovery of new chemical entities against multiple drug resistant (MD 01 Jan 2015 Chemical genetic approach for discovery of new chemical entities against multiple drug resistant (MD 49.45 Lakhs ICMR
Interplay of small RNAs and Hfq in gene expression control in Acinetobacter baumannii: novel mechani 01 Jan 2016 Interplay of small RNAs and Hfq in gene expression control in Acinetobacter baumannii: novel mechani Interplay of small RNAs and Hfq in gene expression control in Acinetobacter baumannii: novel mechani DBT
Development of a bacterial pesticide degrading system for bioremediation of pesticides accumulated i 01 Jan 2015 Development of a bacterial pesticide degrading system for bioremediation of pesticides accumulated i 12.5 Lakhs UCOST
Hazard characterization and isolation of pesticide degrading bacteria for mitigating the environment 01 Jan 2011 Hazard characterization and isolation of pesticide degrading bacteria for mitigating the environment 8.5 Lakhs UCOST




Publications

 

Year: 2023

  • Shadan, A., Pathak, A., Ma, Y., Pathania, R., & Singh, R. P. Deciphering the virulence factors, regulation, and immune response to Acinetobacter baumannii infection (2023). Frontiers in Cellular and Infection Microbiology, 13, 156.
  • Saini, M., Gaurav, A., Kothari, A., Omar, B. J., Gupta, V., Bhattacharjee, A., & Pathania, R. . Small Molecule IITR00693 (2-Aminoperimidine) Synergizes Polymyxin B Activity against Staphylococcus aureus and Pseudomonas aeruginosaACS Infectious Diseases(2023) 9(3), 692-705. 

Year: 2022

  • Kumar, P., Shaikh, A. A., Kumar, P., Gupta, V. K., Dhyani, R., Sharma, T. K., ... Pathania, R. & Navani, N. K. (2022). Double-Edged Nanobiotic Platform with Protean Functionality: Leveraging the Synergistic Antibacterial Activity of a Food-Grade Peptide to Mitigate Multidrug-Resistant Bacterial Pathogens. ACS Applied Materials & Interfaces.
  • Dubey, V., Devnath, K., Gupta, V. K., Kalyan, G., Singh, M., Kothari, A., ... & Pathania, R. "Disulfiram enhances meropenem activity against NDM-and IMP-producing carbapenem-resistant Acinetobacter baumannii infections". Journal of Antimicrobial Chemotherapy (2022): 77(5), 1313-1323.

Year: 2021

  • Gaurav, A., Gupta, V., Shrivastava, S. K., & Pathania, R. "Mechanistic insights into synergy between nalidixic acid and tetracycline against clinical isolates of Acinetobacter baumannii and Escherichia coli". Communications biology (2021): 4(1), 1-12.
  • Dubey, V., Gupta, R., and Pathania, R. , “Targeting Superoxide dismutase confers enhanced Reactive Oxygen Species mediated eradication of Polymyxin B induced Acinetobacter baumannii persisters .” Antimicrobial Agents and Chemotherapy (2021): doi: 10.1128/AAC.02180-

Year: 2020

  • Gaurav, A, Kothari, A, Omar, B, and Pathania, R.. " Assessment of polymyxin B-doxycycline combination against Pseudomonas aeruginosa in in vitro and in a mouse acute pneumonia model."; International Journal of Antimicrobial Agents (2020): 106022.
  • Uppalapati, S.R., Sett, A. and Pathania, R. "The outer membrane proteins OmpA, CarO and OprD of Acinetobacter baumannii confer a two-pronged defense in facilitating its success as a potent human pathogen". Frontiers in microbiology, (2020) 11.

Year: 2019

  • Bhando, T., Bhattacharyya, T., Gaurav, A., Akhter, J., Saini, M., Gupta, V.K., Srivastava, S.K., Sen, H., Navani, N.K., Gupta, V. and Biswas, D., Pathania, R. . "Antibacterial properties and in vivo efficacy of a novel nitrofuran, IITR06144, against MDR pathogens". Journal of Antimicrobial Chemotherapy (2019).
  • Tahlan, S., Kumar, S., Ramasamy, K., Lim, S.M., Shah, S.A.A., Mani, V., Pathania, R. and Narasimhan, B., (2019). Design, synthesis and biological profile of heterocyclic benzimidazole analogues as prospective antimicrobial and antiproliferative agents. BMC Chemistry13(1), p.50.
  • Sharma, A., Gupta, V.K. and Pathania, R.. Efflux pump inhibitors for bacterial pathogens: From bench to bedside. The Indian Journal of Medical Research, (2019149(2), p.129.
  • Ghosh, T., Srivastava, S.K., Gaurav, A., Kumar, A., Kumar, P., Yadav, A.S., Pathania, R. and Navani, N.K. A Combination of Linalool, Vitamin C, and Copper Synergistically Triggers Reactive Oxygen Species and DNA Damage and Inhibits Salmonella enterica subsp. enterica Serovar Typhi and Vibrio fluvialisApplied Environmental Microbiology(2019), 85(4), pp.e02487-18.

Year: 2018

  • Sharma, A., Dubey, V., Sharma, R., Devnath, K., Gupta, V.K., Akhter, J., Bhando, T., Verma, A., Ambatipudi, K.S., Sarkar, M., Pathania, R. The unusual glycine rich C-terminus of the Acinetobacter baumannii RNA chaperone Hfq plays an important role in bacterial physiology, Journal of Biological Chemistry(2018) 293, 13377-13388
  • Gupta, V. K., Gaur, R., Sharma, A., Akther, J., Saini, M., Bhakuni, R. S., & Pathania, R. (2018). A novel bi-functional chalcone inhibits multi-drug resistant Staphylococcus aureus and potentiates the activity of fluoroquinolones. Bioorganic Chemistry. j.bioorg.2018.10.024.

Year: 2017

  • Sharma, A., Sharma, R., Bhattacharyya, T., Bhando, T., Pathania, R. (2017). Fosfomycin resistance in Acinetobacter baumannii is mediated by efflux through a major facilitator superfamily (MFS) transporter—AbaF, Journal of Antimicrobial Chemotherapy, 72, 68–74.
  • Bhattacharyya, T., Sharma, A., Akhter, J., & Pathania, R. (2017). The small molecule IITR08027 restores the antibacterial activity of fluoroquinolones against multidrug-resistant Acinetobacter baumannii by efflux inhibition. International journal of antimicrobial agents50(2), 219-226.

Year: 2016

  • Srivastava, S. K., Iyer, V. R., Ghosh, T., Lambadi, P. R., Pathania, R., & Navani, N. K. (2016). Isolation of a non-genomic origin fluoroquinolone responsive regulatory element using a combinatorial bioengineering approach. Nucleic acids research. 44(5), 2451-2461.

Year: 2015

  • Lambadi, P. R., Sharma, T. K., Kumar, P., Vasnani, P., Thalluri, S. M., Bisht, N., Pathania, R. and Navani, N. K. (2015). Facile biofunctionalization of silver nanoparticles for enhanced antibacterial properties, endotoxin removal, and biofilm control. International journal of nanomedicine. 10, 2155.

Year: 2014

  • Srivastava, S. K., Lambadi, P. R., Ghosh, T., Pathania, R., & Navani, N. K. (2014). Genetic regulation of spy gene expression in Escherichia coli in the presence of protein unfolding agent ethanol. Gene. 548(1), 142-148.
  • Sharma, R., Arya, S., Patil, S. D., Sharma, A., Jain, P. K., Navani, N. K., & Pathania, R. (2014). Identification of novel regulatory small RNAs in Acinetobacter baumanniiPloS one. 9(4), e93833.

Year: 2013

  • Patil, S.D., Sharma, R., Srivastava, S.K., Navani, N.K. and Pathania, R. (2013) Downregulation of yidC in Escherichia coli by antisense RNA expression results in sensitization to antibacterial essential oils eugenol and carvacrol. PLoS ONE. 8(3), e57370.
  • Ghosh, I., Patil, S.D., Sharma, T.K., Srivastava, S.K., Pathania, R. and Navani, N.K. (2013) Synergistic action of cinnamaldehyde with silver nanoparticles against spore-forming bacteria; a case for judicious use of silver nanoparticles for antibacterial applications. International Journal of Nanomedicine .8, 4721-4731.

Year: 2012

  • Iyer, V.R., Sharma, R., Pathania, R. and Navani, N.K. (2012) Small RNAs of Pathogenic Bacteria: Not Small Enough to be overlooked for Therapeutics. Molecular and Cellular Pharmacology .4(1), 17-30. 
  • Sharma, T.K., Sapra, M., Chopra, A., Sharma, R., Patil, S.D., Pathania, R. and Navani, N.K. (2012) Interaction of bacteriocin-capped silver nanoparticles with food pathogens and their antibacterial effect. International Journal of Green Nanotechnology. 4(2), 93-110.
  • Sharma, T.K., Chopra, A., Sapra, M., Kumawat, D., Patil, S.D., Pathania, R. and Navani, N.K. (2012) Green Synthesis and Antimicrobial Potential of Silver Nanoparticles. International Journal of Green Nanotechnology .4(1), 1-16.
  • Bhatia, A., Ali, M., Jitendra, S., Madan, S., Pathania, R., Ahmed,N., Kazmi. A.A. (2012) Microbial diversity during rotary drum and windrow pile composting. Journal of Basic Microbiology .52, 5–15.
  • Bhatia, A., Madan, S., Jitendra, S., Ali, M., Pathania, R., Kazmi, A, A. (2012) Diversity of bacterial isolates during full scale rotary drum composting. Waste Management .33, 1595- 1601. 

Year: 2009

  • Pathania, R., Zlitni, S., Barker, C., Das, R., Gerritsma, D., Lebert, J., Awuah, E., Melacini, G., Capretta, F. and Brown, E. (2009) Chemical genomics in Escherichia coli identifies an inhibitor of bacterial lipoprotein targeting. Nature Chemical Biology. 5, 849-856.
  • Mok, W., Navani, N.K., Barker,C., Sawchyn,B., Gu, J., Pathania, R.,  Zhu, R., Brown, E. and  Yingfu Li. (2009) Identification of a toxic peptide through bidirectional expression of small RNAs. Chembiochem .10, 238-241.

Year: 2008

  • Pathania, R. and Brown, E.D (2008) Small and lethal: searching for new antibacterial compounds with novel modes of action. Biochemistry and Cell Biology .86(2)111-5.

Year: 2002

  • Pathania, R., Navani,N.K., Rajmohan, G. and Dikshit, KL. (2002) Mycobacterium tuberculosis   hemoglobin HbO associates with membranes and stimulates cellular respiration of recombinant E.coliJournal of Biological Chemistry .277(18), 15293-15302. 
  • Pathania, R., Navani,N.K., Gardner, A.M., Gardner, P.M. and Dikshit, KL. (2002) Nitric oxide scavenging and detoxification by the Mycobacterium tuberculosis hemoglobin, HbN, in E. coli. Molecular Microbiology. 45(5):1303-14
  • Ramandeep, Pathania, R., Sharma, V., Mande, S.C., & Dikshit, K.L. (2002). Chimeric Vitreoscilla hemoglobin (VHb) carrying flavoreductase domain relieves nitrosative stress in E. coli: new insight into the functional role of VHb. Applied and Environmental Microbiology .68, 152-160.

 

Books

Year: 2019

  • Gaurav A., Sharma A., Pathania R. (2019) Efflux Mediated Co-resistance. In: Mandal S., Paul D. (eds) Bacterial Adaptation to Co-resistance. Springer, Singapore.
  • Bhando T., Dubey V., Pathania R. (2019) Biofilms in Antimicrobial Activity and Drug Resistance. In: Mandal S., Paul D. (eds) Bacterial Adaptation to Co-resistance. Springer, Singapore
  • Dubey, V., Arya, S., Sen, D., Sharma, A. and Pathania, R., (2019). Computational Prediction of sRNA in Acinetobacter baumannii. In Acinetobacter baumannii (pp. 307-320). Humana Press, New York, NY.

Year: 2013

  • Aradhana Chopra, Tarun   Kumar Sharma, Ranjana Pathania and  Naveen Kumar Navani. (2013). Aptamer – nanoparticles based nanobiosensor for bacterial detection. Studium press LLC, USA.
  • Mahak Sapra, Tarun   Kumar Sharma, Piyush Kumar, Ranjana Pathania and Naveen Kumar Navani. (2013) Nanoparticles based optical detection of xenobiotics small molecules. Studium press LLC, USA.

Year: 2010

  • Himanshu Joshi, Babita Sinha, Ranjana Pathania and P.K. Ghosh. (2010) Knowledge Sharing and Intellectual Property Management - Status and Strategies. LAP Lambert Academic Publishing. ISBN 978-3-8383-2070-0, 244 Pages.

Year: 2004

  • Ranjana Pathania, Govindan Rajamohan and Kanak L. Dikshit. (2004). Novel hemoglobis of M. Tuberculosis: Role in pathogenicity and cellular metabolism. In “Deep Roots Open Skies: New Biology in India”. Eds S.K.Basu, K.K.Batra and D.M. Salunake. pp. 163-166, 2004
Patents

Granted

  • R. Pathania, Timsy Bhando, Ananth Casius. Methods and composition for identification of novel anti-persister activity of GRAS compounds.  Indian Patent Office. (Patent application No. 424983). (2023)
  • E. D. Brown, R. Pathania and F. Capretta. A novel lead series of antibacterial compounds with activity against Gram-negative bacteria. (2008). WO/2008/025152.
  • E. D. Brown, X. Li, G. Wright, J. Cechetto, M. Juran, R. Hartlen and R. Pathania. Method of inhibiting dihydrofolate reductase; screening assay for the identification of novel therapeutics and their cellular targets. (2005).US 7524644
  • G. Rajamohan, M. Dahiya, R. Pathania and K.L. Dikshit. Method for oxygen regulated production of recombinant staphylokinase. (2005). US 20050019862

 

Filed

  • “A composition comprising of 2-aminoperimidine and polymyxin B for the treatment of multidrug-resistant bacterial topical infections”. R. Pathania, Mahak Saini (Patent Application no. 202211033140). (2022).
  • "A therapeutic composition for the treatment of resistant and Persistent Bacterial Infections". R. Pathania, Timsy Bhando. Indian Patent Office. (Patent application No.201911043932). (2018) (Patent filed).

 

Honors And Awards
Honors
National Academy of Sciences, India (NASI)
2022
Elected Fellow of National Academy of Sciences, India (NASI)
DBT/Wellcome Trust India Alliance
2022
DBT/Wellcome Trust India Alliance senior fellowship
The National Academy of Sciences India (NASI)
2020
Malti Purohit Memorial Award
Students
SuperVisions
A computational and mechanistic approach to beta lactamase inhibition.
02 Jan 2023 - Present
Other Supervisors: , Scholar: Perwez Bakht
Alternative strategies to combat MDR gram-negative bacterial pathogens and their persisters.
18 Jul 2022 - Present
Other Supervisors: , Scholar: Arsalan Hussain
deciphering small non-coding RNA mediated regulation of quinate metabolism in Acinetobacter baumannii
18 Jul 2022 - Present
Other Supervisors: , Scholar: Shivam Pandey
Understanding the role of small RNA in pathophysiology and virulence of A. baumannii
17 Aug 2020 - Present
Other Supervisors: , Scholar: Avik Pathak
To study the role of RNA chaperone in nutrient stress of Acinetobacter baumannii
01 Jan 2019 - Present
Other Supervisors: , Scholar: Abhiroop Sett
To study the mode of novel antimicrobial molecules
01 Jan 2019 - Present
Other Supervisors: , Scholar: Rinki Gupta
Studies on role of sRNA in Acinetobacter baumannii upon desiccation stress
01 Jan 2018 - Present
Other Supervisors: , Scholar: Kuldip Devnath
Studies on small RNA based regulation of stress response in A. baumannii
03 Jan 2017 - Present
Other Supervisors: , Scholar: Somok Bhowmik
Chemcial genetics for NCE and antibacterial drug discovery
04 Jan 2016 - 30 Apr 2023
Other Supervisors: , Scholar: Mahak Saini
Deciphering the mode of action and pharmacokinetic potential of novel antibacterial agents
04 Jan 2015 - 06 Jul 2021
Other Supervisors: , Scholar: Jawed Akhter
Combination strategies against persistence and resistance in Acinetobacter baumannii
04 Jan 2015 - 22 Jul 2021
Other Supervisors: , Scholar: Vineet Dubey
Studies on combinations of antibacterial molecules against MDR Acinetobacter baumannii
01 Jan 2014 - 10 Sep 2020
Other Supervisors: , Scholar: Amit Gaurav
Identification and characterization of small RNA from the genetic islands of Acinetobacter baumannii
01 Jan 2013 - 18 Sep 2019
Other Supervisors: , Scholar: Timsy Bhando
Studies on novel small RNA and their targets in Acinetobacter baumannii
01 Jan 2012 - 02 Jan 2019
Other Supervisors: , Scholar: Atin Sharma
Chemical genetic approaches to combat multi drug resistance in Gram negative bacteria
01 Jan 2010 - 16 Feb 2016
Other Supervisors: , Scholar: Tapas Bhattacharyya
Metagenomic approach to study microbes from Himalayan geothermal springs
01 Jan 2009 - 29 Aug 2014
Other Supervisors: , Scholar: Jitendra Kumar Sahoo
Antibacterial activity of soil bacilli and potential of essential ‘Y’ genes as drug targets
01 Jan 2008 - 22 Aug 2013
Other Supervisors: , Scholar: Supriya Deepak Patil
Identification and characterization of small RNA from Acinetobacter baumannii MTCC 1425
01 Jan 2008 - 29 Aug 2013
Other Supervisors: , Scholar: Rajnikant Sharma
Associate Scholars
Dr. Mangal Singh (PDF)
Department of Biotechnology, Indian Institute of Technology Roorkee
Identification of novel adjunct molecules to revive the activity of carbapenems against carbapenem resistant Gram negative pathogens
Vineet Dubey (DBT-SRF)
Department of Biotechnology, Indian Institute of Technology Roorkee
Combination strategies against persistence and resistance in Acinetobacter baumannii
Jawed Akhter (ICMR-SRF)
Department of Biotechnology, Indian Institute of Technology Roorkee
Deciphering the mode of action and pharmacokinetics potential of novel antibacterial agents
Mahak Saini (MHRD-SRF)
Department of Biotechnology, Indian Institute of Technology Roorkee
Chemcial genetics for NCE and antibacterial drug discovery
Somok Bhowmik (UGC-SRF)
Department of Biotechnology, Indian Institute of Technology Roorkee
Studies on small RNA based regulation of stress response in A. baumannii
Kuldip Devnath (INSPIRE-SRF)
Department of Biotechnology, Indian Institute of Technology Roorkee
Studies on role of sRNA in Acinetobacter baumannii upon desiccation stress
Rinki Gupta (DBT-SRF)
Department of Biotechnology, Indian Institute of Technology Roorkee
To study the mode of novel antimicrobial molecules
Abhiroop Sett (MHRD-SRF)
Department of Biotechnology, Indian Institute of Technology Roorkee
To study the role of RNA chaperone in nutrient stress of Acinetobacter baumannii
Avik Pathak (CSIR-JRF)
Department of Biotechnology, Indian Institute of Technology Roorkee
sRNA based regulation in A. baumannii
Miscellaneous
Administrative Positions
Chairperson
01 Jan 2020 - Present
Institute Biosafety Committee