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Debabrata Sircar
Professor
debabrata.sircar[at]bt.iitr.ac.in
Biosciences and Bioengineering Department, IIT Roorkee
Research Interests

Biosketch
Educational Details
Professional Background

Research
Projects
Publications
Patents
Books
Collaborations

Honours and Awards
Honors
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Teaching Engagements
Teaching Engagements

Students
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Associate Scholars

Miscellaneous
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Miscellaneous
Research Interests
Developing early warning sensors for predicting economically significant plant diseases in rice, apples, and potatoes non-destructively and asymptomatically. Farmers will be able to make timely pest management decisions based on these forecasts, Plant immunity: analyzing metabolic basis through mass spectrometry-based metabolomics, The development of non-destructive sensors that analyze fruit quality and predict postharvest shelf lives based on signature metabolites, A metabolomics and functional genomics approach to improve apple fruit quality, focusing on scab resistance, Improved and sustainable production of value-added metabolites by engineering specialized plant metabolic pathways in selected medicinal plants
BioSketch
Educational Details
University of Burdwan, West Bengal
2004
M.Sc, Plant Science
Indian Institute of Technology Kharagpur
2009
Ph.D., Plant Biology
University of Evora, Portugal
2011
FCT, Post-doctoral fellow, Molecular Plant Breeding research
Institute for Pharmaceutical Biology, TU-Braunschweig, GERMANY
2013
Post-doctoral fellow, Functional Genomics and Metabolomics research
Professional Background
Full Professor
11 Oct 2023 - Present
Indian Institute of Technology Roorkee
Associate Professor
18 Dec 2018 - 10 Oct 2023
Indian Institute of Technology Roorkee
Assistant Professor
02 Apr 2013 - 17 Dec 2018
IIT Roorkee
Post-doctoral Fellow
01 Jul 2011 - 30 Mar 2013
IPB, TU-Braunschweig, GERMANY
Post-doctoral Fellow
01 Jun 2010 - 30 Jun 2011
University of Evora, PORTUGAL
Research
Projects
TOPIC START DATE FIELD DESCRIPTION FINANCIAL OUTLAY FUNDING AGENCY OTHER OFFICERS
Development of Bioelectronic Sensor Technology Coupled with High-Throughput Metabolomics for Quality Control 30 Oct 2023 Jatamansi 99.00 DBT India
Development of sensors for blast and blight diseases and stomata activity measurement in rice 01 Jun 2019 (Non-invasive Sensor for early disease detection in plant) 82.00 ICAR Prof. A K Sharma and Prof. Partha Roy as Co-PI
Development of a metabolite-based non-invasive sensor for early scab-disease diagnosis 01 Jun 2022 (Metabolomics, Sensor in Agriculture) 107.0 Lkahs ICAR Partha Roy, Kaushik Ghosh, Harsh Chauhan
Non-invasive early sensing of soft rot and dry rot in stored potato tubers by analysis of volatile organic compound emission 25 Mar 2021 (Metabolomics; Non-invasive Sensors in Agriculture) 49.0 Lkahs SERB D Sircar as PI, Partha Roya and Indranil Lahiri as Co-PI
Development of a bioelectronic sensor for non-destructive early detection of rice sheath blight 30 Sep 2023 in rice The development of an early warning sensor for asymptomatic detection of sheath-blight in rice using VOC biomarkers. Farmers will be able to make timely pest management decisions based on these forecasts 49.80 MOE-STAR
Detection of Spoiled Coconut at Pre–Processing Stage by Portable Wireless Electronic Sensor. 01 Jun 2017 (Non-invasive Sensors in Agriculture) 56.00 Coconut Development Board Prof. Partha Roy and Prof. N P Pathak as Co-PI
A Comprehensive and Scientific Validation of Nutritional, Biological and Stability Properties of High-Altitude Indian Honey 01 Jul 2022 (Scientific Validation of Honey) 32.0 National Bee Board PI is Prof. Partha Roy, Co-PI is Prof. D Sircar
Development of an electronic nose for the optimum harvesting time and fruit quality in Apple and Papaya. 01 Jun 2017 ((Non-invasive Sensors in Agriculture) 139.40 ICAR NASF N P Pathak and Partha Roy as Co-PI
Molecular analyses of the phytoalexin biosynthesis in Apple: 01 Jan 2014 (Metabolomics in Agriculture) 23.00 Lakhs SERB Fast Track
Assessment of the role of Indian mustard honey towards management and cure of drug resistance colon cancer 01 Jul 2021 Validation of Honey 39.0 Lakhs National Bee Board PI is Prof Partha Roy, Co-PI is D Sircar
Generation of BMPR-1B gene edited goats using CRISPR/Cas technology to explore the functional role o 01 Jan 2019 (CRISPR /Cas technology) 65.00 ICAR Prof. Partha Roy as PI
Assessment of the role of pterostilbene and its derivatives for the prevention of bone loss in breas 01 Jan 2016 (Metabolomics) 52.6 DBT Prof. Partha Roy as PI
Assessment of the mechanism of actions of some selected Homeopathic preparations for their role in t 01 Jan 2018 (Validation of traditional medicine) 44.00 AYUSH Prof. Partha Roy as PI
Pathophysiology of Bipolar disorder 01 Jul 2021 Bipolar disorder 131.0 Ljahs SKAN Research Trust, Puducherry PI is Prof. Partha Roy, Co-PI is Prof. D Sircar
Deciphering molecular mechanisms of HsfA2 mediated heat stress responses in transgenic barley 30 Mar 2020 Stress Biology 48.0 Lakhs SERB Harsh Chauhan as PI, D Sircar as Co-PI
Screening iron, zinc and carotenoid bioavailability from biofortified staple crops using coupled in 01 Jan 2015 (Bioassay) 44.8 DBT Prof. Partha Roy as PI
Development of a rapid and robust high throughput reporter cell based bioassay for detection of xeno 01 Jun 2018 (Reporter based assay, sensors) 224.00 ICAR NASF (as Co-PI) Partha Roy (as PI)




Collaborations
Metabolomics and Functional Genomics of Rosaceous Plants.
TU-BS-Germany
Metabolomics and Fluxomics analyses of plants
IIT Mandi
Metabolomics based sensor for rice disease detection
Shivnadar University and BHU
Volatomics based sensor
OUAT, Bhubaneswar
SMART Cell for medicinal plants
JNU
SMART sensor for quality assurance of medicinal plant
NBRI LUcknow
Sub-cellular Localization of phytolaexin biosynthesis proteins in Rosaceae
Institute of Plant Biology, TU-BS, Germany
Alternative oxidase gene as functional marker candidate metabolic re-programming.
University of Evora, PORTUGAL
Health protective Phytomedicine from selected Indian medicinal plants
IIT Kharagpur
Molecular breeding in apple and pear
ICAR-CITH, Srinagar
Metabolic flux analyses in natural product Biosynthesis
IIT Mandi
Publications

86. Ray R, Singh SS, Yadav SR, Sircar D (2024) A nondestructive asymptomatic early disease prediction method employing ROS-induced differential volatile emissions from dry rot-infected potatoes. Plant Physiology and Biochemistry 208, 108532

 

85. Demiwal P, Nabi S, Mir JI, Verma MK, Yadav SR, Roy P, Sircar D (2024) Methyl jasmonate improves resistance in scab-susceptible Red Delicious apple by altering ROS homeostasis and enhancing phenylpropanoid biosynthesis. Plant Physiology and Biochemistry 207, 108371

 

84. Demiwal P, Tayade S, Yadav SR, Sircar D (2024) A metabolomics perspective on root-derived plant immunity and phytohormone interaction. Physiologia Plantarum. DOI: 10.1111/ppl.14150

 

83. Kumari A, Kumar A, Mandal S, Roy P, Sircar D* (2023) A metabolic reprogramming in Bacopa monnieri plants induced by methyl-jasmonate and enhanced biosynthesis of triterpene saponins. Industrial Crops and Products. 204, 117241

 

82. Kumar A, Kumari A, Demiwal P, Roy P, Sircar D* (2023) Enhanced production of bioactive plumbagin in hairy root cultures and adventitious root cultures of Plumbago zeylanica L. by a novel apocarotenoid elicitor, α-ionone. Industrial Crops and Products. 203, 117140

 

81. Nathani S, Das N, Katiyar P, Waghmode B, Sircar D, Roy P (2023) Consumption of honey ameliorates lipopolysaccharide-induced intestinal barrier dysfunction via upregulation of tight junction proteins. European Journal of Nutrition. 62 (7), 3033-3054

 

80. Nathani S, Mishra R, Katiyar P, Sircar D, Roy P (2023) Zinc acts synergistically with berberine for enhancing its efficacy as an anti-cancer agent by inducing clusterin-dependent apoptosis in HT-29 colorectal cancer cells. Biological Trace Element Research. 201 (8), 3755-3773

 

79. Varshney AK, Pathak NP, Sircar D (2023) A single feed graphene-based circularly polarized antenna for THz applications.

 

78. Varshney AK, Pathak NP, Sircar D (2023) Low-profile metasurface-based dual-band graphene patch nanoantenna. Nano Communication Networks. 35, 100428

 

77. Revuru B, Thashanamoorthi G, Demiwal P, Sircar D, Ramalingam S (2023) SmERF6 promotes the expression of terpenoid pathway in Salvia officinalis and improves the production of high value abietane diterpenes, carnosol and carnosic acid. bioRxiv. 2023.11. 23.568411

 

76. Varshney AK, Pathak NP, Sircar D (2022) Low-profile frequency reconfigurable graphene-based dipole antennas loaded with wideband metasurface for THz applications. Plasmonics. 17 (6), 2351-2363

 

75. Varshney AK, Pathak NP, Sircar D (2022) Frequency reconfigurable dielectric lens antenna with graphene nano-antenna feed for THz applications. Optik. 271, 170112

 

74. Kumar M, Agrawal PK, Roy P, Sircar D (2022) GC-MS-based metabolomics reveals dynamic changes in the nutritionally important metabolites in coconut meat during nut maturation. Journal of Food Composition and Analysis. 114, 104869

 

73. Singh H, Singh Z, Zhu T, Xu X, Waghmode B, Garg T, Yadav S, Sircar D, Smet ID, Yadav SR(2022) Auxin-responsive (phospho) proteome analysis reveals key biological processes and signaling associated with shoot-borne crown root development in rice. Plant and Cell Physiology. 63 (12), 1968-1979

 

72. Agrawal H, Thakur K, Mitra S, Mitra D, keswani C, Sircar D, Onteru S, Singh D, Singh SP, Tyagi RK, Roy P (2022) Evaluation of (anti) androgenic activities of environmental xenobiotics in milk using a human liver cell Line and androgen receptor-based promoter-reporter assay. ACS omega. 7 (45), 41531-41547

 

71. Kumar A, Semwal R, Chauhan A, Semwal RB, Chandra S, Sircar D, Roy P, Semwal DK (2022) Evaluation of antidiabetic effect of Cissampelos pareira L.(Menispermaceae) root extract in streptozotocin-nicotinamide-induced diabetic rats via targeting SGLT2 inhibition. Phytomedicine Plus. 2 (4), 100374

 

70. Varshney AK, Pathak NP, Sircar D* (2022) Low-profile dipole antennas based on graphene plasmonics for THz applications.

 

69. Juneja K, Beuerle T, Sircar D* (2022) Enhanced accumulation of biologically active coumarin and furanocoumarins in callus culture and field-grown plants of Ruta chalepensis through led light-treatment. Photochemistry and Photobiology. 98:100-1009

 

68. Sirohi P, Chaudhary C, Baliyan S, Vishnoi R, Mishra SK, Chaudhary R, Waghmode B, Poonia AK, Germain H, Sircar D, Chauhan H (2022) Chloroplast activity provides in vitro regeneration capability in contrasting cultivars. bioRxiv. 2022.06. 30.498295

 

67. Bhutkar M, Rani R, Pathak A, Kothiala A, Mahajan S, Waghmode B, Kumar R, Singh V, Sircar D, Kumar P, Tomar S (2022) Elucidation of antiviral mechanisms of natural therapeutic molecules herbacetin and caffeic acid phenethyl ester against chikungunya and dengue virus. bioRxiv. 2022.05. 31.494145

 

66. Das N, Nathani S, Kumar V, Agrawal H, Sircar D, Roy P (2022) Nutraceuticals for prevention and treatment of cancer. Handbook of Nutraceuticals and Natural Products: Biological, Medicinal, and Nutritional Properties and Applications. 2, 45-90

 

65. Katiyar P, Ghosh S, Saini S, Ghosh C, Agrawal H,  Sircar D, Roy P (2022) Antioxidant nutraceuticals as novel neuroprotective agents. Handbook of Nutraceuticals and Natural Products: Biological, Medicinal, and Nutritional Properties and Applications. 1, 127-168

 

64. Kumar V, Ghosh S, Saini S, Agrawal H, Milind DP, Sircar D, Roy P (2022) Pro‐angiogenic and anti‐angiogenic effects of phytochemicals as Nutraceuticals. Handbook of Nutraceuticals and Natural Products: Biological, Medicinal, and Nutritional Properties and Applications. 2, 91-141

63. Varshney AK, Pathak NP, Sircar D (2023) Low-profile metasurface-based dual-band graphene patch nanoantenna. Nano Communication Networks 35: 100428         

62. Garg T, Singh Z, Chennakesavulu K, Mushahary KKK, Dwivedi AK, Sircar D, Chandran D, Prasad K, Jain M, Yadav SR (2022) Species-specific function of conserved regulators in orchestrating rice root architecture. Development 149: dev200381        

61. Juneja K, Beuerle T, Sircar D* (2022) Enhanced accumulation of biologically active coumarin and furanocoumarins in callus culture and field-grown plants of Ruta chalepensis through led light-treatment. Photochemistry and Photobiology. 98:100-1009

60. Kumar M, Agrwal PK, Roy P, Sircar D* (2022) GC-MS-based metabolomics reveals dynamic changes in the nutritionally important metabolites in coconut meat during nut maturation. Journal of Food Composition and Analysis, 114: 104869        

59. Das N, Samantaray S, Ghosh C, Kushwaha K, Sircar D, Roy P (2022) Chimaphila umbellata extract exerts anti-proliferative effect on human breast cancer cells via RIP1K/RIP3K-mediated necroptosis. Phytomedicine Plus. 2(1): 100159

58. Ghosh C, Das N, Saha S, Kundu T, Sircar D, Roy P (2022) Involvement of Cdkal1 in the etiology of type 2 diabetes mellitus and microvascular diabetic complications: a review. Journal of Diabetes & Metabolic Disorders. 1-11, DOI: https://doi.org/10.1007/s40200-021-00953-6

57. Mahto JK, Neetu N, Waghmode B, Kuatsjah E, Sharma M, Sircar D, Sharma AK, Tomar S, Eltis LD, Kumar P (2021) Molecular insights into substrate recognition and catalysis by phthalate dioxygenase from Comamonas testosterone. Journal of Biological Chemistry. 297(6)

56. Varshney AK, Pathak NP, Sircar D (2021) Radiation pattern reconfigurable graphene plasmonics-based nanoantenna. Journal of Nanophotonics. 15(4):046007

 

55. Singh H, Singh Z, Zhu T, Xu X, Waghmode B, Garg T, Yadav S, Sircar D, Smet ID, Yadav SR (2021) Auxin-responsive (phospho) proteome analysis reveals key biological processes and signaling associated with shoot-borne crown root development in Rice. Plant and Cell Physiology. DOI: https://doi.org/10.1093/pcp/pcab155

54. Kumar V, Haldar S, Das NS, Ghosh S, Dhankhar P, Sircar D, Roy P (2021) Pterostilbene-isothiocyanate inhibits breast cancer metastasis by selectively blocking IKK-β/NEMO interaction in cancer cells. Biochemical Pharmacology. 192:114717

53. Waghmode B, Masoodi L, Kushwaha K, Mir JI, Sircar D* (2021) Volatile components are non-invasive biomarkers to track shelf-life and nutritional changes in apple cv. ‘Golden Delicious’ during low-temperature postharvest storage. Journal of Food Composition and Analysis. 102:104075

52. Thakur LS, Varma AK, Goyal H, Sircar D, Mondal P (2021) Simultaneous removal of arsenic, fluoride, and manganese from synthetic wastewater by Vetiveria zizanioides. Environmental Science and Pollution Research. 28(32):44216-44225

51. Banerjee S, Katiyar P, Kumar L, Kumar V, Saini SS, Krishnan V, Sircar D, Roy P (2021) Black pepper prevents anemia of inflammation by inhibiting hepcidin over-expression through BMP6-SMAD1/IL6-STAT3 signaling pathway. Free Radical Biology and Medicine. 168:189-202

50. Kushwaha K, Saini SS, Waghmode B, Gaid M, Agrawal PK, Roy P, Sircar D* (2021) Volatile components in papaya fruits are the non‑invasive biomarkers to monitor the ripening stage and the nutritional value. European Food Research and Technology. 247:907–919

49. Tomar V, Das N, Chauhan H, Roy P, Sircar D* (2021) Closed polybag foliar methyl-jasmonate treatment: New technology for rapid enhancement of bioactive withanolide biosynthesis in field-grown plants of Withania somnifera. Industrial Crops & Products. 162:113262

48. Banerjee S, Katiyar P, Kumar V, Saini SS, Varshney R, Krishnan V, Sircar D, Roy P (2021) Black pepper and piperine induce anticancer effects on leukemia cell line. Toxicology Research. 10(2):169-182

47. Kumar M, Saini SS, Agrawal PK, Roy P, Sircar D* (2021) Nutritional and metabolomics characterization of the coconut water at different nut developmental stages. Journal of Food Composition and Analysis. 96:103738

46. Garg T, Singh Z, Chennakesavulu K, Dwivedi AK, Varapparambathu V, Singh RS, Mushahary KK, Yadav M, Sircar D, Chandran D, Prasad K, Jain M, Yadav SR (2021) Genome-wide high resolution expression map and functions of key cell fate determinants reveal the dynamics of crown root development in rice. BioRxiv. 2020.06. 11.131565

45. Mishra R, Das N, Varshney R, Juneja K, Sircar D, Roy P (2021) Betel leaf extract and its major component hydroxychavicol promote osteogenesis and alleviate glucocorticoid-induced osteoporosis in rats. Food & Function. 12(14):6603-6625

44. Bharadwaj R, Noceda C, Mohanapriya G, Kumar SR, Thiers KL, Costa JH, Macedo ES, Kumari A, Gupta KJ, Srivastava S, Adholeya A, Oliveira M, Velada I, Sircar D, Sathishkumar R, Arnholdt-Schmitt B (2021) Adaptive reprogramming during early seed germination requires temporarily enhanced fermentation- A critical role for alternative oxidase regulation that concerns also microbiota effectiveness. Frontiers in plant science. DOI: https://doi.org/10.3389/fpls.2021.686274

43. Costa JH, Mohanapriya G, Bharadwaj R, Noceda C, Thiers KLL, Aziz S, Srivastava S, Oliveira M, Gupta KJ, Kumari A, Sircar D, Kumar SR, Achra A, Sathishkumar R, Adholeya A, Arnholdt-Schmitt B (2021) ROS/RNS balancing, aerobic fermentation regulation and cell cycle control - a complex early trait ('CoV-MAC-TED') for combating SARS-CoV-2-induced cell reprogramming. Frontiers in immunology.12:673692. DOI: 10.3389/fimmu.2021.673692.

42. Arnholdt-Schmitt B, Mohanapriya G, Bharadwaj R, Noceda C, Macedo ES, Sathishkumar R, Gupta KJ, Sircar D, Kumar SR, Srivastava S, Adholeya A, Thiers KL, Aziz S, Velada I, Oliveira M, Quaresma P, Achra A, Gupta N, Kumar A, Costa JH (2021) From plant survival under severe stress to anti-viral human defense–a perspective that calls for common efforts. Frontiers in Immunology. DOI: 10.3389/fimmu.2021.673723

41. Singh H, Singh Z, Zhu T, Xu X, Waghmode B, Garg T, Yadav S, Sircar D, Smet ID, Yadav SR (2021) Auxin-responsive (phospho) proteome analysis reveals regulation of cell cycle and ethylene signaling during rice crown root development. Plant and Cell Physiology. DOI: https://doi.org/10.1093/pcp/pcab155

40. Banerjee S, Katiyar P, Kumar V, Waghmode B, Nathani S, Krishnan V, Sircar D, Roy P (2021) Wheatgrass inhibits the lipopolysaccharide-stimulated inflammatory effect in RAW 264.7 macrophages. Current research in toxicology. 02:116-127

39. Varshney AK, Pathak NP, Sircar D (2020) Dipole antenna based on graphene plasmonics over the AMC surface. 2020 IEEE Asia-Pacific Microwave Conference (APMC). 151-153

38. Nathani S, Kumar V, Dhaliwal HS, Sircar D, Roy P (2020) Biological application of a fluorescent zinc sensing probe for the analysis of zinc bioavailability using Caco-2 cells as an in-vitro cellular model. Journal of Fluorescence. 30(6):1553-1565

37. Mishra R, Nathani S, Varshney R, Sircar D, Roy P (2020) Berberine reverses epithelial-mesenchymal transition and modulates histone methylation in osteosarcoma cells. Molecular Biology Reports. 47(11):8499-8511

36. Varshney AK, Pathak NP, Sircar D (2020) Non-destructive detection of coconut quality using RF sensor. Electronics Letters. 56(19): 975-977

35. Semwal DK, Chauhan A, Semwal RB, Sircar D, Roy P, Lehmann J (2020) Natural molecules having anti-SARS-CoV activity-cannot they be effective against SARS-CoV-2. Current Science. 119(5), 757-770

34. Mishra T, Sircar D, Dhaliwal HS, Singh N(2020) Spectroscopic and chromatographic characterization of crude natural shilajit from Himachal Pradesh, India. The Natural Products Journal.10(3):244-256

33. Saini SS, Gaid M, Sircar D (2020) Benzoate-CoA ligase contributes to the biosynthesis of biphenyl phytoalexins in elicitor-treated pear cell cultures. Plant Cell Reports. 39(2): 207-215

32. Varshney AK, Pathak NP, Sircar D, (2020) Non-destructive detection of coconut quality using RF sensor. Electronic Letter. 56:975-77

31. Juneja K, Mishra R,  Chauhan S, Gupta S, Roy P, Sircar D* (2020) Metabolite profiling and wound-healing activity of Boerhavia diffusa leaf extracts using in vitro and in vivo models. Journal of Traditional and Complementary Medicine. (10): 52-5930.

30. Teotia D, Gaid M, Saini SS, Verma A, Yennamalli RM, Khare SP, Ambatipudi K, Mir JI,  Beuerle T, Hänsch R, Roy P, Agrawal PK, Beerhues L, Sircar D* (2019) Cinnamate: CoA‐ligase is involved in benzoate‐derived biphenyl phytoalexin biosynthesis in Malus× domestica ‘Golden Delicious'. Plant Journal.  100: 1176-1192

29. Saini SS, Teotia D, Gaid MM, Sircar D* (2019) A New Enzymatic Activity from Elicitor treated Pear Cell Cultures Converting trans‐Cinnamic acid to Benzaldehyde. Physiologia Plantarum. 167: 64-74

28. Saini SS, Gaid M, Sircar D* (2019) Benzoate-CoA ligase contributes to the biosynthesis of biphenyl phytoalexins in elicitor-treated pear cell cultures. Plant cell reports. 1-9. DOI: https://doi.org/10.1007/s00299-019-02484-0

27. Tomar V, Beeurle T, Sircar D* (2019) A validated HPTLC method for the simultaneous quantifications of three phenolic acids and three withanolides from Withania somnifera plants and its herbal products. J Chromatogr B. 1124:154-60

26. Chaudhary R, Baranwal VK , Kumar R, Sircar  D,  Chauhan H (2019) Genome-wide identification and expression analysis of Hsp70, Hsp90, and Hsp100 heat shock protein genes in barley under stress conditions and reproductive development. Functional & Integrative Genomics. 19: 1007-1022

25. Varshney R, Mishra R, Das N, Sircar D, Roy P (2019) A comparative analysis of various flavonoids in the regulation of obesity and diabetes: An in vitro and in vivo study. Journal of Functional Foods. 59:194–205

24. Mishra R, Varshney R, Das N, Sircar D, Roy P (2019) Synthesis and characterization of gelatin-PVP polymer composite scaffold for potential application in bone tissue engineering. European Polymer Journal. 119:155-168

23. Varshney AL, Pathak NP, Sircar D* (2019) Design of graphene-based THz antennas. Computing, Communication and Signal Processing. 29-35

22. Liu B, Gaid M, Chizzali C, Khalil MNA, Sircar D, Reckwell,D, Beerhues  L (2019)Biphenyls and dibenzofurans are the phytoalexins of apple. Acta horticulturae. DOI: 10.17660/ActaHortic.2019.1261.37

21. Varshney AL, Pathak NP, Sircar D* (2018) Beam Steering THz Antenna Array using Graphene-based Phase Shifter 2018 IEEE Indian Conference on Antennas and Propagation (InCAP), 1-4

20. Sarkate A, Saini SS, Gaid M, Teotia D, Mir JI, Agrawal PK, Beerhues L, Sircar D*(2018) Comparative metabolomics of scab-resistant and susceptible apple cell cultures in response to scab fungus elicitor treatment. Scientific Reports. 8(1):17844

19. Sarkate A, Saini SS, Gaid M, Teotia D, Mir JI, Agrawal PK, Beerhues L, Sircar D.*(2018) Molecular Cloning and Functional Analysis of a Biphenyl Phytoalexin-specific O-methyltransferase from Apple Cell Suspension Cultures. Planta. 249(3):677-691

18. Varshney R, Varshney R, Mishra R, Gupta S, Sircar D, Roy P (2018) Kaempferol alleviates palmitic acid-induced lipid stores, endoplasmic reticulum stress and pancreatic β-cell dysfunction through AMPK/mTOR-mediated lipophagy. Journal of Nutritional Biochemistry. 57: 212-27

17. Sarkate A, Saini SS, Kumar P, Sharma AK, Sircar D* (2018) Salicylaldehyde synthase activity from Venturia inaequalis elicitor-treated cell culture of apple. J Plant Physiol. 221: 66-73.

16. Saini SS, Teotia D, Gaid M, Thakur A, Beerhues L, Sircar D* (2017) Benzaldehyde dehydrogenase-driven phytoalexin biosynthesis in elicitor treated Pyrus pyrifolia cell cultures. J Plant Physiol. 215: 154-62.

15. Sarkate A, Banerjee S, Mir JI, Roy P, Sircar D* (2017) Antioxidant and cytotoxic activity of bioactive phenolic metabolites isolated from the yeast-extract treated cell culture of apple. Plant Cell Tissue Organ Culture. 130:641-49.

14. Teotoa D, Saini SS, Gaid M, Beuerle T, Beerhues L, Sircar D * (2016) Development and Validation of a New HPLC Method for the Determination of Biphenyl and Dibenzofuran Phytoalexins in Rosaceae. J Chromatogr Sci. (2016) doi: 10.1093/chromsci /bmw019.

13. Mukherjee C, Sircar D, Chatterjee M, Das S, Mitra A (2014) Combating photooxidative stress in green hairy roots of Daucus carota cultivated under light irradiation. J Plant Physiol. 171: 179-87.

12. Sircar D, Gaid M, Chizzali C, Reckwell D, Kaufholdt D, Beuerle T, Broggini GA, Flachowsky H, Liu B, Haensch R, Beerhues L (2015). Biphenyl 4-Hydroxylases Involved in Aucuparin Biosynthesis in Rowan and Apple are CYP736A Proteins. Plant Physiology. 168: 428-442

11. Gaid MM#Sircar D#, Müller A, Beuerle T, Liu B, Ernst L, Hänsch R, Beerhues L (2012): Cinnamate:CoA ligase initiates the biosynthesis of a benzoate-derived xanthone phytoalexin in Hypericum calycinum cell cultures. Plant Physiology 160: 1267-80 [# - joint first author].

10. Moon UR, Sircar D, Barthwal R, Sen SK, Beuerle T, Beerhues L, Mitra A (2015). Shoot cultures of Hoppea fastigiata (Griseb.) C.B. Clarke as potential source of neuroprotective xanthones. J Nat Med DOI 10.1007/s11418-015-0904-x

9.  Santos-Mecedo E#Sircar D#, Cardoso H, Peixe A, Arnholdt-Schmitt B (2012): Involvement of alternative oxidase (AOX) in adventitious rooting of Olea europaea L. microshoots is linked to adaptive phenylpropanoid and lignin metabolism. Plant Cell Rep. 31: 1581-90; [# - joint first author].

8.  Sircar D*, Cardoso HG, Mukherjee C, Mitra A, Arnholdt-Schmidt B (2012): Alternative oxidase (AOX) and phenolic metabolism in methyl-jasmonate-treated hairy root cultures of Daucus carota L. J. Plant Physiol 169: 657-663.

7.  Sircar, D., Mukherjee, C., Beuerle, T., Beerhues, L. and Mitra A. (2011): Characterization of p-hydroxybenzaldehyde dehydrogenase - the final enzyme of p-hydroxybenzoic acid biosynthesis in hairy roots of Daucus carotaActa Physiol Plantarum 33:2019-2024.

6.  Sircar, D. and Mitra A. (2009): Accumulation of p-hydroxybenzoic acid in hairy roots of Daucus carota 2.Confirming biosynthetic steps through feeding of inhibitors and precursors. J. Plant Physiol. 166, 1370-1380.

5.   Gaid, MM.,# Sircar, D.,# Beuerle, T., Mitra, A. and Beerhues, L. (2009): Benzaldehyde dehydrogenase from chitosan-treated Sorbus aucuparia cell cultures. J. Plant Physiol. 166, 1343-1349. [# - joint first author].

4.  Chakraborty, D.,# Sircar, D.and Mitra A. (2008): Phenylalanine ammonia-lyase-mediated biosynthesis of 2-hydroxy-4-methoxybenzaldehyde in roots of Hemidesmus indicus. J. Plant Physiol.  165, 1033-1040. [#- joint first author].

3.  Sircar, D  and Mitra, A. (2008): Evidence for p-hydroxybenzoate formation involving enzymatic phenylpropanoid side-chain cleavage in hairy roots of Daucus carota. J. Plant Physiol165, 407-414.

2.   Sircar, D., Dey, G. and Mitra A. (2007): A validated HPLC method for simultaneous determination of 2-hydroxy-4-methoxybenzaldehyde and 2-hydroxy-4-methoxybenzoic acid in root organs of Hemidesmus indicusChromatographia. 65, 349-353. (IF= 1.09).

1.   Sircar, D., Roychowdhury, A. and Mitra, A. (2007): Accumulation of p-hydroxybenzoic acid in hairy roots of Daucus carotaJ. Plant Physiol.  164, 1358-1366. 

Patents

1. D. Sircar, P. Roy, N.P. Pathak, M. Kumar, B. Wagmode, K. Kushwaha, A Kumar. A portable sensing device and a method for rapid and non-destructive determination of the quality of coconuts. Indian Patent No. 441113. Granted on 28.07.2023

2. D. Sircar, P. Roy, N.P. Pathak, M. Kumar, B. Wagmode, K. Kushwaha, A Kumar. A portable bioelectronic sensor for easy non-destructive prediction of fruit ripening stage and selected fruit physicochemical parameters of apple. Indian Patent Appl. No. 202211002188 dated. 13/01/2022

 

A.        Book Chapters

 1.        Sharma N, Sircar D* (2023) Bioactive Alkaloids from Tinospora cordifolia. The Essential Guide to Alkaloids (Deepak Kumar Semwal (eds.), NOVA Science Publisher. https://doi. 10.52305/KXUM3530

 

2.         Varshney AK, Pathak NP, Sircar D. (2021) Full-Wave Analysis of Graphene-Based Circular Patch Antenna. Proceedings of Integrated Intelligence Enable Networks and Computing .Singh Mer, K.K., Semwal, V.B., Bijalwan, V., Crespo, R.G. (eds).Springer, Singapore. https://doi.org/10.1007/978-981-33-6307-6_75

3.          Tomar V, Saini SS, Juneja K, Agrawal PK, Sircar D* (2019) Transgenic Technologies and Their Potential Applications in Horticultural Crop Improvement. Advances in Plant Transgenics: Methods and Applications (R. Sathishkumar et al. (eds.), Springer Nature Singapore Pte Ltd. https://doi.org/10.1007/978-981-13-9624-3_9

4.          Juneja K, Saini SS, Gaid M, Beerhues L, Sircar D* (2017) Production of life-saving drugs from Himalayan herbs. Sustainable Utilization of Natural Resources (Mondal, P., Dalai, A.K., eds.), CRC Press, Boca Raton, USA Chapter 11:333-352.

5.          Mitra A, Mukherjee C, Sircar D (2017) Metabolic Phytochemistry-Based Approaches for Studying Secondary Metabolism Using Transformed Root Culture Systems. In: Jha S. (eds) Transgenesis and Secondary Metabolism. Reference Series in Phytochemistry. Springer, Cham. Chapter 20: 513-37

6.          Nogales A, Noceda C, Ragonezi C, Cardoso H G, Campos M D, Frederico A M, Sircar D, Kumar S R,  Polidoros A, Peixe A  and Arnholdt-Schmitt B  (2015) Functional marker development from  AOX  genes requires deep phenotyping and individualized diagnosis, in Alternative respiratory pathways in higher plants (eds K. J. Gupta, L. A.J. Mur and B. Neelwarne), John Wiley & Sons, Ltd, Chichester, UK. Chapter 13.1: 273-2080.

 

 

Books

 

1.       Sharma N, Sircar D* (2023) Bioactive Alkaloids from Tinospora cordifolia. The Essential Guide to Alkaloids (Deepak Kumar Semwal (eds.), NOVA Science Publisher. https://doi.10.52305/KXUM3530

 

2.    Varshney AK, Pathak NP, Sircar D. (2021) Full-Wave Analysis of Graphene-Based Circular Patch Antenna. Proceedings of Integrated Intelligence Enable Networks and Computing .Singh Mer, K.K., Semwal, V.B., Bijalwan, V., Crespo, R.G. (eds).Springer, Singapore. https://doi.org/10.1007/978-981-33-6307-6_75

3.       Tomar V, Saini SS, Juneja K, Agrawal PK, Sircar D* (2019) Transgenic Technologies and Their Potential Applications in Horticultural Crop Improvement. Advances in Plant Transgenics: Methods and Applications (R. Sathishkumar et al. (eds.), Springer Nature Singapore Pte Ltd. https://doi.org/10.1007/978-981-13-9624-3_9

4.          Juneja K, Saini SS, Gaid M, Beerhues L, Sircar D* (2017) Production of life-saving drugs from Himalayan herbs. Sustainable Utilization of Natural Resources (Mondal, P., Dalai, A.K., eds.), CRC Press, Boca Raton, USA Chapter 11:333-352.

5.         Mitra A, Mukherjee C, Sircar D (2017) Metabolic Phytochemistry-Based Approaches for Studying Secondary Metabolism Using Transformed Root Culture Systems. In: Jha S. (eds) Transgenesis and Secondary Metabolism. Reference Series in Phytochemistry. Springer, Cham. Chapter 20: 513-37

6.         Nogales A, Noceda C, Ragonezi C, Cardoso H G, Campos M D, Frederico A M, Sircar D, Kumar S R,  Polidoros A, Peixe A  and Arnholdt-Schmitt B  (2015) Functional marker development from  AOX  genes requires deep phenotyping and individualized diagnosis, in Alternative respiratory pathways in higher plants (eds K. J. Gupta, L. A.J. Mur and B. Neelwarne), John Wiley & Sons, Ltd, Chichester, UK. Chapter 13.1: 273-2080.

 

 

 

 

 

 

 

Honors And Awards
Honors
Indian Institute of Technology Roorkee
2019
Institute Research Fellow (IRF) for performing outstanding research at IIT Rorokee
IIT Roorkee
2015
DAAD Research Stays for University Academics and Scientists
SERB India
2013
SERB Young Scientist
Institute for Pharmaceutical Biology, TU-Braunschweig, GERMANY
2020
Post-doctoral fellowship
Laboratory of molecular biology, University of Evora; PORTUGAL
2010
FCT Post-doctoral felloship (with evaluation score 5/5))
Institute for Pharmaceutical Biology, TU-Braunschweig, GERMANY
2008
DAAD Fellowship
The University of Burdwan, West Bengal
2004
University First, gold medal in M.Sc Botany
Vinoba Bhave University
2001
University first in B.Sc Botany
Teaching Engagements
Teaching Engagements
Cell Biology ( BTN 104 )
Spring
Plant System Physiology ( BTN 642 )
Spring
Plant Biotechnology ( BTN 303 )
Autumn
Cell and Tissue Cult Technology ( BTN 621 )
Autumn
Recombinant DNA Technology ( BTN 657 )
Autumn
Students
SuperVisions
BIOSYNTHESIS OF BENZOATE-DERIVED BIPHENYL PHYTOALEXINS IN CELL CULTURES OF PYRUS PYRIFOLIA
01 Jan 2014 - 17 Dec 2017
Other Supervisors: , Scholar: Dr. Shashank Sagar Saini
BIOCHEMICAL AND MOLECULAR ANALYSES OF PHYTOALEXIN BIOSYNTHESIS IN APPLE CELL CULTURES
01 Jan 2013 - 24 Feb 2018
Other Supervisors: , Scholar: Dr. Amol Sarkate
THE ENHANCEMENT OF CONTENT OF BIOACTIVE METABOLITES IN ECONOMICALLY IMPORTANT MEDICINAL PLANTS BOERHAVIA DIFFUSA AND RUTA CHALEPENSIS
16 Aug 2015 - 07 Mar 2022
Other Supervisors: , Scholar: Dr. Kriti Juneja
MOLECULAR ANALYSIS OF CINNAMATE COA-LIGASE FROM PHYTOALEXIN PRODUCING APPLE CELL CULTURES
14 Aug 2013 - 03 Jul 2018
Other Supervisors: , Scholar: Dr. Deepa Teotia
NUTRITIONAL PROFILE OF PAPAYA FRUIT AND NON-INVASIVE PREDICTION OF RIPENING STAGES OF PAPAYA USING VOLATILE BIOMARKERS
21 Aug 2017 - 07 Feb 2023
Other Supervisors: , Scholar: Dr. Komal Kushwaha
METABOLOMIC STUDIES FOR ASSESSMENT OF NUTRITIONAL VALUE OF COCONUT THROUGH DIFFERENT NUT DEVELOPMENTAL STAGES
22 Aug 2016 - 14 Sep 2022
Other Supervisors: , Scholar: Dr. Mukund Kumar
ANALYSIS OF VOLATILE ORGANIC COMPOUNDS TO PREDICT APPLE RIPENING AND SHELF-LIFE
07 Jul 2020 - 11 Jul 2023
Other Supervisors: , Scholar: Dr. Wahmode Bhairabhnath
ENHANCED PRODUCTION OF BIOACTIVE WITHANOLIDES FROM WITHANIA SOMNIFERA: A METABOLOMICS APPROACH
01 Dec 2016 - 10 Jul 2023
Other Supervisors: , Scholar: DR. K M VARSHA
GRAPHENE PLASMONICS-BASED ON-CHIP TERAHERTZ ANTENNAS
01 Jan 2016 - 14 Jul 2023
Other Supervisors: Prof. N P Pathak, ECE Department, IIT Roorkee, Scholar: Dr. Arun Kumar Varshney
METABOLOMICS-BASED BIOACTIVITY ASSESSMENT OF PLUMBAGO ZEYLANICA
07 Jul 2020 - 13 Oct 2023
Other Supervisors: , Scholar: Dr. Ashwani Kumar
ROLE OF SALICYLIC ACID MEDIATED METABOLIC REPROGRAMMING IN SCAB RESISTANCE MECAHNISMS IN APPLE
25 Dec 2017 - 30 May 2024
Other Supervisors: , Scholar: Ms. Pratibha
ENHANCED IN PLANTA AND IN VITRO BIOACCUMULATION OF PHARMACEUTICALLY IMPORTANT TRITERPENOID SAPONINS IN Bacopa species
30 Dec 2017 - 30 May 2024
Other Supervisors: , Scholar: Ms. Annu Kumari
Miscellaneous
Events
International Conference on ‘Molecular Signaling: Recent Trends in Biomedical and Translational Res
07 Jul 2020 - Present
DBT, SERB, DRDO, INSA, NDRC
Invited Talk: 23rd National convention of society of pharmacognosy and international conferences on
07 Jul 2020 - Present
NBRI
Invited Talk: SEMINAR ON Emerging Trends in Bioprospecting of Phytoresources by Chemistry & Bioprosp
01 Jan 2019 - Present
FRI, DEHRADUN
Invited Talk: International conference on Conservation and sustainable use of high altitude medicina
01 Jan 2019 - Present
National Medicinal Plants Board, Ministry of AYUSH
Linking R & D with stakeholders & Entrepreneurs
01 Jan 2018 - Present
Expert member for SEMINAR on Emerging Trends in Bioprospecting of Phytoresources.
01 Jan 2019 - Present
Indo-US conference and workshop on “Recent Advances on Structural Biology and Drug Discovery
07 Jul 2020 - Present
DBT, SERB, DRDO, INSA, NDRC and Indo-US
Invited Talk: 6th Biennial International Conference on New Developments in Drug Discovery from Natur
07 Jul 2020 - Present
NIPER, Mohali
Precision Agriculture in India- Way Forward
01 Jan 2018 - Present
Recent Advances in Ayurvedic herbal medicine- from source to manufacturing (Invited Talk)
07 Jul 2020 - Present
IIT Roorkee
XV Annual convention of ISVPT (Invited Talk)
07 Jul 2020 - Present
SERB Young Scientist Grant
Research Stays for University Academics and Scientists 2015
01 Jan 2015 - Present
4th International Conf. and Exhibition on Pharmacognosy, Phytochemistry and Nat Prod (Invited Talk)
07 Jul 2020 - Present
IIT Roorkee
International Conference on Molecular Signaling- Recent Trends in Biosciences (Invited Talk)
07 Jul 2020 - Present
IIT Roorkee
Administrative Positions
Member Secretary IBSC
01 Jan 2015 - Present
Institutional Biosafety Committee
Coordinator DBT M.Sc. Biotechnology Programme
14 May 2020 - 01 Jun 2025
IIT Roorkee
Officer In-Charge Administration
01 Jan 2015 - Present
Biotechnology Department IIT Roorkee
Officer In-Charge Store & Purchase
01 Jan 2014 - Present
Biotechnology Department IIT Roorkee
Member DAC (Departmental Research Committee)
01 Jan 2014 - Present
Biotechnology Department IIT Roorkee
Particulars of course
- Courses currently teaching: B.Tech: Plant Biotechnology (BTN 303) Cell Biology (BTN 104) M. Sc: Cell and Tissue Culture Technology (BTN 621) Plant System Physiology (BTN 642) M.Sc Project (BTN 620) M.Tech: Recombinant DNA Technology (BTN 657) New Course Developed: Plant System Physiology (BTN 642)
Innovation in teaching
- Interactive teaching with audio-video quizes