Research Interests
3D Image Segmentation, Computational Soft X-ray tomography, Applied Machine Learning, Computational Cryo-electron tomography, Computational Cell Structural Biology, Computational Biology, ArtScience, Pattern Mining
BioSketch
Research
Mechanistic and structural insights into EstS1 esterase: A potent broad-spectrum phthalate diester degrading enzyme
2024
Shalja Verma, Shweta Choudhary, Kamble Amith Kumar, Jai Krishna Mahto, Ishani Mishra, Vellanki Bhanu Prakash, Debabrata Sircar, Shailly Tomar, Ashwani Kumar Sharma, Jitin Singla, Pravindra Kumar | Elsevier
Journal: Structure
Structure-guided mutations in CDRs for enhancing the affinity of neutralizing SARS-CoV-2 nanobody
2024
Vishakha Singh, Mandar Bhutkar, Shweta Choudhary, Sanketkumar Nehul, Rajesh Kumar, Jitin Singla, Pravindra Kumar, Shailly Tomar | Academic Press
Journal: Biochemical and Biophysical Research Communications Pages: 150746 , Volumes: 734 ,
In-silico characterization of a hypothetical protein of Sulfobacillus sp. hq2 for degradation of phthalate diesters
2024
Shalja Verma, Anika Singh, Pravindra Kumar, Jitin Singla | Elsevier
Journal: International Journal of Biological Macromolecules Pages: 136006 , Volumes: 280 ,
Sāmayik: A Benchmark and Dataset for English-Sanskrit Translation
2024
Ayush Maheshwari, Ashim Gupta, Amrith Krishna, Ganesh Ramakrishnan, G Anil Kumar, Jitin Singla | European Language Resources Association
Journal: LREC-COLING2024
Designing and bioengineering of CDRs with higher affinity against receptor-binding domain (RBD) of SARS-CoV-2 Omicron variant
2024
Vishakha Singh, Shweta Choudhary, Mandar Bhutkar, Sanketkumar Nehul, Sabika Ali, Jitin Singla, Pravindra Kumar, Shailly Tomar | Cold Spring Harbor Laboratory
Journal: bioRxiv
Characterization of haloacid dehalogenase superfamily acid phosphatase from Staphylococcus lugdunensis
2024
Harry Kaur, Surabhi Rode, KP Sandra, Jai Krishna Mahto, Md Shahid Alam, Deena Nath Gupta, Bibekananda Kar, Jitin Singla, Pravindra Kumar, Ashwani Kumar Sharma | Academic Press
Journal: Archives of Biochemistry and Biophysics Pages: 109888 , Volumes: 753 ,
On Learning with LAD
2024
CA Jothishwaran, Biplav Srivastava, Jitin Singla, Sugata Gangopadhyay | Cornell University
Journal: arXiv preprint
Database Evolution, by Scientists, for Scientists: A Case Study
2023
Shuler, R.E., Singla, J., Vallat B., White, K.L., Berman, H.M. & Kesselman C. | IEEE
Journal: IEEE eScience 2023
An Intensity-based Post-processing Tool for 3D Instance Segmentation of Organelles in Soft X-ray Tomograms
2022
Li, A., Zhang, S., Loconte, V., Liu, Y., Ekman, A., Thompson, G.J., Sali, A., Stevens, R.C., White, K., Singla, J., Sun, L. | PLOS
Journal: PLOS One
A New Visual Design Language for Biological Structures in a Cell
2022
Singla, J., Burdsall, K., Cantrell, B., Halsey, J. R., McDowell, A., McGregor, C., ... & Berman, H. M. | CellPress
Journal: Structure Pages: 485-497 , Volumes: 30 (4) ,
Auto-segmentation and time-dependent systematic analysis of mesoscale cellular structure in ?-cells during insulin secretion
2022
Li A., Zhang X., Singla J., White K., Loconte V., Hu C., Zhang C., … & Stevens R.C. | PLOS
Journal: PLOS One Pages: e0265567 , Volumes: 17 (3) ,
Soft X-ray tomography to map and quantify organelle interactions at the mesoscale
2022
Loconte, V., Singla, J., Li, A., Chen, J.H., Ekman, A., McDermott, G., Sali, A., White, K.L. and Larabell, C.A. | CellPress
Journal: Structure Pages: 510-521 , Volumes: 30 (4) ,
A community approach to whole-cell modeling
2021
Singla, J. and White, K.L. | Elsevier
Journal: Current Opinion in Systems Biology Pages: 33-38 , Volumes: 26 ,
Assessment of scoring functions to rank the quality of 3D subtomogram clusters from cryo-electron tomography
2021
Singla, J., White, K. L., Stevens, R. C., and Alber, F. | Elsevier
Journal: Journal of Structural Biology Pages: 107727 , Volumes: 213 (2) ,
Bayesian metamodeling of complex biological systems across varying representations
2021
Raveh, B., Sun, L., White, K.L., Sanyal, T., Tempkin, J., Zheng, D., Pilla, K.B., Singla, J., Wang, C., … & Sali, A. | National Academy of Sciences
Journal: PNAS Pages: e2104559118 , Volumes: 118 (35) ,
Visualizing subcellular rearrangements in intact ? cells using soft x-ray tomography
2020
White, K. L., Singla, J., Loconte, V., Chen, J. H., Ekman, A., Sun, L., Zhang, X., … & Stevens, R. C. | American Association for the Advancement of Science
Journal: Science Advances Pages: eabc8262 , Volumes: 6 (50) ,
Visualizing insulin vesicle neighborhoods in ? cells by cryo–electron tomography
2020
Zhang, X., Carter, S. D., Singla, J., White, K. L., Butler, P. C., Stevens, R. C., and Jensen, G. J. | American Association for the Advancement of Science
Journal: Science Advances Pages: eabc8258 , Volumes: 6 (50) ,
De Novo Structural Pattern Mining in Cellular Electron Cryotomograms
2019
Xu, M., Singla, J., Tocheva, E. I., Chang, Y. W., Stevens, R. C., Jensen, G. J., and Alber, F. | CellPress
Journal: Structure Pages: 679-691 , Volumes: 27 (4) ,
Opportunities and challenges in building a spatiotemporal multi-scale model of the human pancreatic ? cell
2018
Singla, J., McClary, K. M., White, K. L., Alber, F., Sali, A., and Stevens, R. C. | CellPress
Journal: Cell Pages: Nov-19 , Volumes: 173 (1) ,
Understanding the functional impact of copy number alterations in breast cancer using a network modeling approach
2016
Srihari, S., Kalimutho, M., Lal, S., Singla, J., Patel, D., Simpson, P. T., Khanna, K. K., and Ragan, M. A. | Royal Society of Chemistry
Journal: Molecular BioSystems Pages: 963-972 , Volumes: 12 (3) ,
Inferring synthetic lethal interactions from mutual exclusivity of genetic events in cancer
2015
Srihari, S., Singla, J., Wong, L., and Ragan, M. A. | BioMed Central
Journal: Biology direct Pages: Jan-18 , Volumes: 10 (1) ,
Honors And Awards
Teaching Engagements
Miscellaneous
