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Sachin Suresh Tiwari
Assistant Professor
sachin.tiwari[at]bt.iitr.ac.in
Office : F-8, Old Biotech Building
+91-1332-285389
https://sites.google.com/view/sst-ndrlgroup
Research Interests

Biosketch
Educational Details
Professional Background

Research
Projects
Publications
Patents
Books
Collaborations

Honours and Awards
Honors
Memberships

Teaching Engagements
Teaching Engagements

Students
Supervisions
Associate Scholars

Miscellaneous
Events
Visits
Administrative Positions
Miscellaneous
Research Interests
Neuroscience, Neurodegeneration, Alzheimer's Disease
BioSketch
Educational Details
Kings College London
2015
PhD, Neuroscience
University of Delhi -South Campus
2010
Masters, Genetics
Professional Background
Assistant Professor
01 Feb 2022 - Present
Indian Institute of Technology Roorkee
Ramalingaswami Fellow/Scientist-D
01 Jan 2020 - 31 Jan 2022
AIIMS-Delhi
Postdoctoral Research Scientist
01 May 2016 - 31 Dec 2019
University of Edinburgh , United Kingdom
Program Specific Researcher
01 Feb 2015 - 31 Jan 2016
Kyoto University, Japan
Visiting Student Fellow
01 Aug 2010 - 01 Feb 2011
EPFL, Switzerland
Research
Projects
TOPIC START DATE FIELD DESCRIPTION FINANCIAL OUTLAY FUNDING AGENCY OTHER OFFICERS
Tau Transfer 11 Dec 2022 Neurodegeneration and Synaptic Mechanism NA DST-SERB
Investigation of therapeutics in AD 12 Feb 2025 Alzheimer's Disease NA ICMR, India Prof. Puneet Gupta (CoPI)
Dysregulation of Autophagy mechanisms 05 Apr 2019 AD NA DBT, Govt of India, India
Nanovesicles in AD 01 Nov 2023 Drug delivery NA Ministry of Education (MoE, Govt of India), India Prof. Gopinath Packirisamy (CoPI)




Publications
  1. Jiwaji, Zoeb, Sachin S. Tiwari*, Rolando X. Avilés-Reyes, Monique Hooley, David Hampton, Megan Torvell, Delinda A. Johnson, Jamie McQueen, Paul Baxter, Kayalvizhi Sabari-Sankar, Jing Qiu, Xin He, Jill Fowler, James Febery, Jenna Gregory, Jamie Rose, Jane Tulloch, Jamie Loan, David Story, Karina McDade, Amy M. Smith, Peta Greer, Matthew Ball, Peter C. Kind, Paul M. Matthews, Colin Smith, Owen Dando, Tara L. Spires-Jones, Jeffrey A. Johnson, Siddharthan Chandran, and Giles E. Hardingham. 2022. “Reactive Astrocytes Acquire Neuroprotective as Well as Deleterious Signatures in Response to Tau and Aß Pathology.” Nature Communications 13(1):135. doi: 10.1038/s41467-021-27702-w. (*Co-first author). 
  2. Ghosh, Anshua, Keiko Mizuno, Sachin S. Tiwari, Petroula Proitsi, Beatriz Gomez Perez-Nievas, Elizabeth Glennon, Rocio T. Martinez-Nunez, and K. Peter Giese. 2020. “Alzheimer’s Disease-Related Dysregulation of MRNA Translation Causes Key Pathological Features with Ageing.” Translational Psychiatry 10(1). doi: 10.1038/s41398-020-00882-7.
  3. Sachin S. Tiwari, Yuki M. Shirai, Yuri L. Nemoto, Kumiko Kojima, and Kenichi G. N. Suzuki. 2018. “Native Prion Protein Homodimers Are Destabilized by Oligomeric Amyloid β 1-42 Species as Shown by Single-Molecule Imaging.” NeuroReport 29(2):106–11.
  4. Hasel, Philip, Owen Dando, Zoeb Jiwaji, Paul Baxter, Alison C. Todd, Samuel Heron, Nóra M. Márkus, Jamie McQueen, David W. Hampton, Megan Torvell, Sachin S. Tiwari, Sean McKay, Abel Eraso-Pichot, Antonio Zorzano, Roser Masgrau, Elena Galea, Siddharthan Chandran, David J. A. Wyllie, T. Ian Simpson, and Giles E. Hardingham. 2017. “Neurons and Neuronal Activity Control Gene Expression in Astrocytes to Regulate Their Development and Metabolism.” Nature Communications 8. doi: 10.1038/ncomms15132.
  5. Sachin S. Tiwari,  Keiko Mizuno, Anshua Ghosh, Wajeeha Aziz, Claire Troakes, Jason Daoud, Vidushi Golash, Wendy Noble, Tibor Hortobágyi, and Karl Peter Giese. 2016. “Alzheimer-Related Decrease in CYFIP2 Links Amyloid Production to Tau Hyperphosphorylation and Memory Loss.” Brain 139(Pt 10):2751–65. doi: 10.1093/brain/aww205.
  6. Sachin S. Tiwari, Marie d’Orange, Claire Troakes, Badrun N. Shurovi, Olivia Engmann, Wendy Noble, Tibor Hortobágyi, and Karl P. Giese. 2015. “Evidence That the Presynaptic Vesicle Protein CSPalpha Is a Key Player in Synaptic Degeneration and Protection in Alzheimer’s Disease.” Molecular Brain 8(1):6. doi: 10.1186/s13041-015-0096-z

 

Honors And Awards
Honors
IIT Roorkee
2022
Ashok Soota New Faculty Fellowship
DBT, Govt of India
2019
Ramalingaswami Fellowship
Alzheimer's Research UK
2014
ARUK Travel grant
European Molecular Biology Organization
2012
EMBO Fellowship
Guarantors of Brain (Journal)
2012
Brain Travel Grant
Kings College London
2011
King's International Graduate Scholarship
Kings College London
2010
King's Overseas Research Student Award
LNMC, EPFL
2010
LNMC Fellowship
Monsanto Inc and University of Delhi
2008
Monsanto Scholarship
Indian Academy of Sciences
2008
UG Summer Research Fellowship
MemberShips
Indian Academy of Neuroscience
01 Dec 2019 - Present
Life Member
International Society for Neurochemistry
01 Jan 2020 - Present
Member
Asian Pacific Society for Neurochemistry
01 Feb 2021 - Present
Member
ISTAART
01 Jun 2023 - Present
Member
Society for Neurochemistry, India (SNCI)
01 Jan 2024 - Present
Life Member
Teaching Engagements
Teaching Engagements
Molecular Neuroscience ( BTN-901 )
Spring
Cell Biology and Genetics ( BEC-203 )
Autumn
Emerging Techniques in Cell and Molecular Biology ( BET-101 )
Spring
Critical Analysis of Classical Papers ( BT-603 )
Autumn
Plant and Animal Biotechnology Lab -III ( BT-510 )
Autumn
Cell Biology ( BE-104 )
Spring
Biotechnology and Genetic Engineering Lab ( BT-517 )
Autumn
Bioprocess Engineering Lab ( BT-534 )
Autumn
Students
SuperVisions
Blood based vesicles in Neurodegenerative disorders
01 Jul 2022 - Present
Other Supervisors: , Scholar: Komal Bana
Autophagy in AD
01 Jul 2022 - Present
Other Supervisors: , Scholar: Divyanshu Darshana
Novel treatment strategies in Alzheimer's
01 Jul 2023 - Present
Other Supervisors: , Scholar: Ishika Gulati
Glial mechanisms in dementia
01 Jan 2024 - Present
Other Supervisors: , Scholar: Shubham Sonwani
Miscellaneous
Visits
Vienna, Austria
2024-06-21
Conference
Administrative Positions
Member-Secretary
03 Oct 2022 - Present
IAEC, IIT Roorkee
Member
01 Jan 2024 - Present
DRC
Professor-in-charge
01 Jul 2022 - Present
Neurodegeneration Research Lab
Member
01 Jan 2023 - 31 Dec 2023
Department Academic Programme Committee (DAPC)
Visits
Detail Country Year
CSHL school on Biology of Memory New York, USA 2011
European Neuropathology Conference Edinburgh , UK 2012
EMBO visiting Fellow University of Debrecen , Hungary 2012
ARUK conference Oxford, UK 2013
Society for Neuroscience Conference San Diego, USA 2013
Resource Facuty, IBRO APRC school on Blood Brain Barrier Chandigarh , India  2019