Research Interests
Virology, Antibody Therapeutics, Immunotherapy, Phage Display, Nanobodies, Single chain antibody fragments (scFv), Antibody Engineering, Camel nanobodies, Shark VNAR nanobodies, Development of Antibody Based Therapeutic Interventions for Emerging and Re-emerging viral diseases
BioSketch
Research
Kyasanur Forest disease virus non-structural protein NS1 forms multimers in solution, with a distinctly identifiable tetrameric state
2025
Rohit Gupta, Shruti Sharma, Anjali Saroj, Rishav Madhukalya, Vivek Kumar, Vidushi Agarwal, Dilip Kumar, Vidya Mangala Prasad, Rajesh Kumar* | Elsevier
Journal: Biochimie Pages: 89-94 , Volumes: 234 ,
Genomic and Structural Insights into Chandipura Virus: A Comparative in Silico Analysis of Indian and West African Strains and Potential Host Receptor Interactions
2025
Megha Gupta, Disharee Mallick, Dilip Kumar, Rajesh Kumar* | Springer
Journal: Current Microbiology Pages: 1-12 , Volumes: 82 ,
The Evolving Landscape of Chandipura Virus: a comprehensive account of Outbreaks to recent advances
2025
Disharee Mallick, Urvashi Yadav, Megha Gupta, Dilip Kumar, Rajesh Kumar* | Elsevier
Journal: Virology Pages: 1-15 , Volumes: 608 ,
Purification and characterization of kyasanur forest disease virus EDIII domain of major envelope glycoprotein
2025
Manjima Das , Vivek Kumar , Rishav Madhukalya , Rohit Gupta , Vidushi Agarwal , Shweta Choudhary, Mandar Bhutkar , Shailly Tomar, Dilip Kumar, Rajesh Kumar | Elsevier
Journal: Journal of Virological Methods Pages: 1-10 , Volumes: Volume 333, April 2025, 115089 ,
SARS‐CoV‐2 infection induces thymic atrophy mediated by IFN‐γ in hACE2 transgenic mice.
2024
Zaigham Abbas Rizvi, Srikanth Sadhu, Jyotsna Dandotiya, Puja Sharma, Akshay Binayke, Virendra Singh, Vinayaka Das, Ritika Khatri, Rajesh Kumar, Sweety Samal, Manjula Kalia, Amit Awasthi | Wiley
Journal: Eur J Immunol Pages: 375-386 , Volumes: April 24 ,
Optimized high-yield expression of envelope glycoprotein domain III from dengue virus serotypes 1 to 4
2024
Disharee Mallick , Vanshika Tyagi , Anjali Saroj, Mandar Bhutkar , Vivek Kumar, Manjima Das, Rishav Madhukalya , Shweta Choudhary , Rohit Gupta , Vishakha Singh, Dilip Kumar, Shailly Tomar, Rajesh Kumar | Elsevier
Journal: Biochimie . Pages: 1-15 , Volumes: Dec 11 ,
Elite neutralizers: An open eye for HIV vaccine development
2024
Ravi Arya, Karthika S Nair, Vivek Kumar, Vidushi Agarwal, Supratik Das, Rajesh Kumar* | Elsevier, USA
Journal: In book: Neuropsychiatric Complications of HIV Pages: 1-20 , Volumes: July ,
Human Immunodeficiency Virus (HIV) and Antibodies: catch 22
2024
Rajesh Kumar, Karthika S Nair, Kalpana Luthra | Elsevier Press, USA
Journal: Book: Neuropsychiatric complications in HIV Pages: 1-22 , Volumes: July ,
Kennedy epitope (KE)-dependent retrograde transport of efficiently cleaved HIV-1 envelopes (Envs) and its effect on Env cell surface expression and viral particle formation
2024
Supratik Das, Hilal Ahmad Parray, Adarsh Kumar Chiranjivi, Prince Kumar, Abhishek Goswami, Manish Bansal, Deepak Kumar Rathore, Rajesh Kumar, Sweety Samal. | Springer
Journal: Protein J Pages: 1-12 , Volumes: 43(2) ,
An overview of anti-Chikungunya antibody response in natural infection and vaccine-mediated immunity, including anti-CHIKV vaccine candidates and monoclonal antibodies targeting diverse epitopes on the viral envelope.
2024
Pankaj Chandley, Asha Lukose, Rajesh Kumar*, Soma Rohatgi*. | Elsevier
Journal: The Microbe Pages: 1-15 , Volumes: 1 ,
A broadly neutralising monoclonal antibody overcomes the mutational landscape of emerging SARS-CoV2 variant of concerns
2022
Hilal Ahmed Parray et al…., Chandresh Sharma*, Amit Awasthi*, Pramod Kumar Garg *, Deepak T Nair*, Rajesh Kumar* | PLos Pathogen
Journal: Plos Pathogens Pages: 1-30 , Volumes: December ,
Characterization of a broadly cross-reactive tetravalent human monoclonal antibody, recognizing conformational epitopes in receptor binding domain of SARS‑CoV‑2.
2022
Sonal Garg, Nisha Raj, Asha Lukose, Deepti Jamwal, Hilal Ahmed Parray, Sandeep Anand, Samridhi Dhyani, Kamini Jakhar, Sudipta Sonar, Mahima Tiwari, Reema, Shailendra Mani, Sankar Bhattacharyya, Chandresh Sharma, Tripti Shrivastava, Rajesh Kumar*. | Springer
Journal: 3 Biotech Pages: 1-5 , Volumes: 12(9):202 ,
SARS-CoV-2 Spike Protein-Activated Dendritic Cell-Derived Extracellular Vesicles Induce Antiviral Immunity in Mice
2022
Anjali Barnwal, Brohmomoy Basu, Aarti Tripathi, Naina Soni , Debasish Mishra, Arup Banerjee , Rajesh Kumar, Sudhanshu Vrati, Jayanta Bhattacharyya | ACS
Journal: ACS Biomaterials Science & Engineering Pages: 5338-5348 , Volumes: 12;8(12) ,
Protocol for High Throughput Screening of Antibody Phage Libraries.
2022
Vanshika Singh, Sonal Garg, Nisha Raj, Asha Lukose, Deepti Jamwal, Reshma Perween, Samridhi Dhyani, Hilal Ahamed Parray, Chandresh Sharma, Rajesh Kumar* | Bio Protocol
Journal: Bio Protocol Pages: 1-20 , Volumes: 20;12(12):e4450 ,
Design and characterization of a germ-line targeting soluble, native-like, trimeric HIV-1 Env lacking key glycans from the V1V2-loop.
2021
Shubbir Ahmed, Tripti Shrivastava, Rajesh Kumar, Mohit Kumar, Manidipa Banerjee, Naresh Kumar, Manish Bansal, Supratik Das, Sweety Samal. | Elsevier
Journal: Biochimica et Biophysica Acta (BBA)-General Subjects Pages: 1-12 , Volumes: 1865(1) ,
Cellular immune responses are preserved and may contribute to Chadox1 ChAdOx1 nCoV-19 vaccine effectiveness against infection due to SARS-CoV-2 B· 1· 617· 2 delta variant.
2022
Thiruvengadam, Ramachandran, Awasthi, Amit, Medigeshi, Guruprasad, Bhattacharya, Sankar, Mani, Shailendra, Sivasubbu, ...Rajesh kumar... Bhattacharya, Jayanta, Agrawal, Anurag, Vrati, Sudhanshu, Bhatnagar, Shinjini, Garg, Pramod Kumar | Lancet
Journal: Lancet Infect Dis . Pages: 473-482 , Volumes: 22(4) ,
Generation of soluble, cleaved, well-ordered, native-like dimers of dengue virus 4 envelope protein ectodomain (sE) suitable for vaccine immunogen design
2022
Adarsh Kumar Chiranjivi , Dilip Kumar, Rajesh Kumar, Hilal Ahmad Parray, Shubbir Ahmed , Chandra Sekhar Kumar , Tripti Shrivastava , Manidipa Banerjee , B V Venkataram Prasad , Supratik Das. | Elsevier
Journal: Int J Biol Macromol . Pages: 1-20 , Volumes: 30;217:19-26 ,
Chikungunya and arthritis: An overview.
2021
R Kumar*, S Ahmed, HA Parray, S Das*. | Elsevier
Journal: Travel Medicine and Infectious Disease, Pages: 1-8 , Volumes: 44:102168 ,
Potent neutralizing antibodies induced in rabbits by an engineered HIV-1 clade C Env derived from an elite neutralizer env sequence demonstrate distinct epitope specificities compared to those elicited in natural infection.
2021
Rajesh Kumar , Suprit Deshpande , Leigh M. Sewall , Gabriel Ozorowski ……..Ashish , Vivek Kumar , Nitin Hingankar , K G Murugavel , A. K Srikrishnan , Devin Sok , Andrew B. Ward , Jayanta Bhattacharya. | Plos Pathogens
Journal: Plos Pathogens Pages: 1-10 , Volumes: 7 ,
Inhalation monoclonal antibody therapy: a new way to treat and manage respiratory infections
2021
Hilal Ahmad Parray , Shivangi Shukla , Reshma Perween , Ritika Khatri , Tripti Shrivastava , Vanshika Singh , Praveenkumar Murugavelu , Shubbir Ahmed , Sweety Samal , Chandresh Sharma , Subrata Sinha , Kalpana Luthra ,Rajesh Kumar*. | Springer
Journal: Applied Microbiology and Biotechnology Pages: 6315-6332. , Volumes: 105(16-17): ,
A rapid novel strategy for screening of antibody phage libraries for production, purification, and functional characterization of amber stop codons containing single-chain antibody fragments (scFvs)
2021
Reshma Perween, Shubbir Ahmed, Tripti Shrivastava, Hilal A Parray, Balwant Singh, Kamal S Pindari, Chandresh Sharma, Shivangi Shukla,, Subrata Sinha, Anil Kumar Panchal, Rajesh Kumar*. | Wiley
Journal: Biotechnology Progress Pages: 1-10 , Volumes: 37(3):e3136 ,
The SARS CoV-2 spike directed non-neutralizing polyclonal antibodies cross-react with Huma immunodeficiency virus (HIV-1) gp41
2021
Reshma Perween, Praveen Kumar, .......... Supratik Das, Kalpana Luthra, Rajesh Kumar. | Elsevier
Journal: International Immunopharmacology Pages: 1-10 , Volumes: Dec;101(Pt B):108187. ,
Inhalation monoclonal antibody therapy: a new way to treat and manage respiratory infections.
2021
Hilal Ahmad Parray , Shivangi Shukla , Reshma Perween , Ritika Khatri , Tripti Shrivastava , Vanshika Singh , Praveenkumar Murugavelu , Shubbir Ahmed , Sweety Samal , Chandresh Sharma , Subrata Sinha , Kalpana Luthra ,Rajesh Kumar*. | Springer
Journal: Applied Microbiology and Biotechnology Pages: 1-17 , Volumes: 105(16-17):6315-6332. ,
Potent neutralizing antibodies induced in rabbits by an engineered HIV-1 clade C Env derived from an elite neutralizer env sequence demonstrate distinct epitope specificities compared to those elicited in natural infection
2021
Rajesh Kumar , Suprit Deshpande , Leigh M. Sewall , Gabriel Ozorowski , Christopher A. Cottrell , Wen-Hsin Lee , Lauren G. Holden , Sara T. Richey, Antra Singh Chandrawacar , ....Devin Sok , Andrew B. Ward , Jayanta Bhattacharya. | Plos Pathogen
Journal: Plos Pathogen Pages: 1-15 , Volumes: April 7 ,
Non-neutralizing SARS CoV-2 directed polyclonal antibodies demonstrate cross-reactivity with the HA glycans of influenza virus
2021
Praveen Kumar, Reshma Perween, Tripti Shrivastava, Vanshika Singh, Hilal Ahmed Parray, Swarandeep Singh, Adarsh Chiranjivi,.........Shinjini Bhatnagar, Kalpana Luthra, Rajesh Kumar* | Elsevier
Journal: International Immunopharmacology Pages: 1-10 , Volumes: Oct;99:108020 ,
The SARS CoV-2 spike directed non-neutralizing polyclonal antibodies cross-react with Huma immunodeficiency virus (HIV-1) gp41.
2021
Reshma Perween, Praveen Kumar, Tripti Shrivastava, Hilal Ahmed Parray, ……Shailendra Mani, Sankar Bhattacharyya, Supratik Das, Kalpana Luthra, Rajesh Kumar. | Elsevier
Journal: International Immunopharmacology Pages: 1-12 , Volumes: 101(Pt B):108187 ,
Identification of an anti-SARS-CoV-2 receptor binding domain directed human monoclonal antibody from a naïve semi-synthetic library
2020
Hilal Ahmad Parray, Adarsh Kumar Chiranjivi, Shailendra Asthana, Naveen Yadav, Tripti Shrivastava, Shailendra Mani, Chandresh Sharma, Priti Vishwakarma, Supratik Das, Kamal Pindari, Subrata Sinha, Sweety Samal, Shubbir Ahmed, Rajesh Kumar* | Elseiver
Journal: Journal of Biological Chemistry Pages: 12814-12821 , Volumes: 295(36) ,
Honors And Awards
BMGF Award, D3 HIV Cure conference held at Durban, KwaZulu-Natal, South Africa on Apr 7 - Apr 10, 2025, Durban, Durban, South Africa
2025
Bill and Melinda Gates Foundation Global Health Award
International AIDS Society (IAS)
2019
Awarded full fellowship to attend the 2019 HIV & HBV Cure Forum on 20 & 21 July 2019 and the 10th IAS Conference on HIV Science (IAS 2019), 20-24 July 2019 in Mexico City, Mexico.
Awarded Merck Young Scientist, award in COVID category
International AIDS Society
2018
Recipient of full scholarship to attend ‘HIV Research for Prevention (HIV R4P )2018 conference to be held at Madrid, Spain from October 21-25, 2018
Antiviral Research Society (AVRS)
2018
Elected as fellow of Antiviral Research Society (AVRS) for the year 2018, based on the outstanding research contribution in the field of viral vaccine.
Research-for-Cure Academy
2018
Awarded full fellowship to attend the Research-for-Cure Academy which will be held at the Wits Rural Facility, Bushbuck Ridge, South Africa from 31 October to 2 November 2018
International AIDS Vaccine Initiative (IAVI), USA
2018
MVP 2018 Award from IAVI,USA for “excellent and outstanding leadership efforts towards successfully establishing the B cell sorting and bnAb isolation platform” at the HVTR lab in THSTI by closely working with NAC.
International AIDS Society
2016
Recipient of full scholarship to attend ‘HIV Research for Prevention 2016: AIDS Vaccine, Microbicide and ARV based Prevention Science (HIVR4P)’conference held at Chicago, USA, Oct., 2016
International AIDS Society
2014
Awarded scholarship to attend the 27thInternational Conference on Antiviral Research at Raleigh Convention Center in Raleigh,North Carolina, USA, from 12-16 May 2014.
SIr Ganga Ram Hospital, New Delhi, India
2014
Awarded Best oral presentation award (second) in 3rd CME of Clinical Biochemistry in SIr Ganga Ram Hospital, New Delhi, India on 23rd March , 2014.
Society of Young Scientists, AIIMS, New Delhi, India.
2014
Awarded Joginder Singh Duggal Memorial Award for best oral presentation by Society of Young Scientists, AIIMS, New Delhi, India.
International AIDS Society
2013
Awarded scholarship to attend the IAS Towards an HIV Cure Symposium in Kuala Lumpur, Malaysia on 29 & 30 June 2013, as well as the 7thIAS Conference on HIV Pathogenesis, Treatment and Prevention, 30June – 3 July 2013 (IAS 2013)
International Union against Sexually Transmitted Infections (IUSTI)
2013
Awarded scholarship to attend the STI & AIDS World Congress 2013 (Joint Meeting of the 20th ISSTDR and 14th IUSTI Meeting), July 14-17, 2013, Vienna, Austria
Bill & Melinda Gates Foundation
2013
Global Health Travel Award recipient for Keystone Symposia on “HIV Vaccines 2013” Colorado USA,
YR Gaitonde Centre for AIDS Research and Education (YRG Care)
2012
HIV SCIENCE-12, Chenni, India, awarded best poster graded II and a medal
International Symposium on HIV and Emerging Infectious Diseases.
2012
Recipient of Travel Award for ISHEID 12, Marseillie, FRANCE.
INTERNATIONAL SOCIETY FOR ANTIVIRAL RESEARCH
2012
Recipient of Travel Award for ICAR 2012, Sapporo, JAPAN
Teaching Engagements
Students
Miscellaneous
