Mala Nath

1. Multifunctional CdSNPs@ZIF-8: Potential Antibacterial Agent against GFP-Expressing Escherichia coli and Staphylococcus aureus and Efficient Photocatalyst for Degradation of Methylene Blue, A. Malik, Mala Nath, S. Mohiyuddin and G. Packirisamy, ACS Omega, 3 (2018) 8288-8308.

2. Structure-cytotoxicity Relationship for Apoptotic Inducers Organotin(IV) Derivatives of Mandelic Acid and L-Proline and their Mixed Ligand Complexes having Enhanced Cytotoxicity, Mala Nath, P. Roy, R Mishra and M. Thakur, Appl. Organomet. Chem. (2018), e4663; DOI: 10.1002/aoc.4663.

3. New diorganotin(IV) complexes of salicylaldehyde based hydrazones bearing furan heterocycle moiety:X-ray structural investigation of dimethyltin(IV) and diphenyl-tin(IV) complexes.Sundeep Kumar and Mala Nath, J. Organomet. Chem., 856 (2018) 87-99.

4.Synthesis, Characterization and Binding Studies of Novel Diorganotin(IV) Complexes of Sodium 2-mercaptoethane-sulfonate. Ranjana Kumari and Mala Nath*, Appl. Organomet. Chem. (2018), DOI: 10.1002/aoc.4365.

5. Synthesis and Characterization of Novel Trimethyltin(IV) and Tributylltin(IV) Complexes of Anticoagulant, WARFARIN: Potential DNA Binding and Plasmid Cleaving Agents, R. Kumari and Mala Nath, Inorg. Chem. Commun., 95 (2018) 40-46.

6. Tri- and diorganotin(IV) derivatives of non-steroidal anti-inflammatory drug, Sulindac: Characterization, electronic structures (DFT), DNA binding, and plasmid cleavage studies. Ranjana Kumari and Mala Nath*, Appl. Organomet. Chem. (2017), doi/10.1002/aoc.e- 3661.

7. Novel Binuclear diorganotin(IV) complexes of adipic acid dihydrazone containing flexible aliphatic spacer: X-ray structural characterization of dimethyltin(IV) complex.Sundeep Kumar and Mala Nath, J. Organomet. Chem., 853 (2017) 113-121.

8.Microwave–assisted synthesis of mixed ligands organotin(IV) complexes of 1,10-phenanthroline and L-proline: physicochemical characterization, DFT calculations,chemotherapeutic potential validation by in vitro DNA binding and nuclease activity. Mala Nath^*, Mridula and Ranjana Kumari, J. Photochem. Photobiol. B: Biology, 174 (2017) 182-194.

9. New triphenyltin(IV) complexes of flexible tripodal Schiff base ligands: X-ray structural characterization of Ph₃SnCl. (H3trensal). Sundeep Kumar and Mala Nath, J. Organomet. Chem., 848 (2017) 10-21.

10.Multi-Core–shell TiO₂NPs@ZIF-8 Composite for Enhanced Photocatalytic Degradation and Adsorption of Methylene Blue and Rhodamine-B,R. Chandra, Mala Nath, Chem. Select., 2 (2017) 7711-7722.

11. TiO₂@ZIF-8: A Novel Approach of Modifying Micro-environment for Enhanced Photo-catalytic Dye Ddegradation and High Usability of TiO₂ Nanoparticles. R. Chandra, S. Mukhopadhyay, M. Nath, Mat. Lett. `164 (2016) 571-574.

12. Conventional and Microwave–assisted Synthesis, Characterization, DFT Calcula-tions, in vitro DNA Binding and Cleavage Studies of Potential Chemotherapeutic Diorganotin(IV) Mandelates. Mridula and Mala Nath^*, J. Photochem. Photobiol. B: Biology, 162 (2016) 348-360.

13. Mode of Action of Tin-based Anti-proliferative Agents: Biological Studies of Organotin(IV) Derivatives of Fatty Acids, M. Nath M. Vats, P. Roy, J. Photo-chem. Pho-tobiol. B: Biology, 148 (2015) 88-100.

14. Tri- and diorganotin(IV) complexes of biologically important orotic acid: Synthesis,spectroscopic studies, in vitro anti-cancer, DNA fragmentation, enzyme assays and in vivo anti-inflammatory activities, M. Nath , M. Vats and P. Roy, Eur. J. of Med. Chem., 59 (2013) 310-321.

15. Chemistry and applications of organotin(IV) complexes of Schiff bases. Perspective, M. Nath and P. K. Saini, Dalton Trans 40 (2011), 7077-7121.

16.. Design and Microwave-assisted Synthesis of Tri- and Dialkyltin(IV) Hippurates, Characterization, In Vitro Anti-cancer and In Vivo Anti-inflammatory Activities, M. Nath, M. Vats, P. Roy, Med. Chem. Res.,24 (2015) 51-62.

17.. Design, Spectral Characterization, Anti-tumor and Anti-inflammatory Activity of Triorganotin(IV) Hydroxyl-carboxylates, Apoptosis Inducers: In Vitro Assessment of Induction of Apoptosis by Enzyme, DNA-fragmentation, Acridine Orange and Comet Assays,M. Nath, M. Vats, P. Roy, Inorg. Chim. Acta, 423 (2014) 70-82.

18..New di- and triorganotin(IV) complexes of tripodal Schiff base ligand containing three imidazole arms: Synthesis, structural characterization, biological activity and thermal studies, M. Nath, P. K. Saini and A. Kumar, J. Organomet. Chem., 695 (2010), 1353–1362.

19. Organotin(IV)tryptophanylglycinates: Potential Non-Steroidal Anti-inflammatory Agents; Crystal Structure of Dibutyltin(IV) tryptophanylglycinate, M. Nath, H. Singh, P. Kumar, A. Kumar, X. Song and G. Eng, Appl. Organomet. Chem., 23 (2009), 347-358.

20.. New Triorganotin(IV) Derivatives of Dipeptides as Anti-inflammatory Anti-microbial Agents, M. Nath, S. Pokharia, G. Eng, X. Song, and A. Kumar, Eur. J. Med. Chem., 40(3), (2005), 289-298.

21. Preparation and Characterization of Li[Mn_2-xFe_x]O₄ (x = 0.0-0.6) Spinel Nanoparticles as Cathode Materials for Lithium Ion Battery, P. Singh, A. Sil, M. Nath, S. Ray, Adv. Mater. Res., 67 (2009) 233-238.

TOPIC	START DATE	FIELD	DESCRIPTION	FINANCIAL OUTLAY	FUNDING AGENCY	OTHER OFFICERS
Organotin(IV) carboxylates and their mixed ligands compounds as potential chemotherapeutics	21 Aug 2018	Organotin Compounds as Anticancer Drugs	Organotin(IV) carboxylates having very low IC50 values could be applied for the development of new anti-cancer drugs. However, the low solubility of organotin compounds poses an important difficulty, which may be partially addressed through the use of hydrophilic groups such as flouro and hydroxyl groups. Therefore, we propose to synthesize new organotin carboxylates with more electronegative hydrophilic substituents and their mixed ligand complexes with heterocyclic N-donors such as o-phenanthroline and benzimidazole derivatives in order to individuate a balance between solubility and lipophilicity features in order to achieve efficacy. We propose to screen all compounds by MTT assay. Further, the mechanisms of action of organotins on biological targets are often different or not well known, so new biophysical techniques along with antioxidant enzymes, staining and DNA fragmentation assays need to be applied to understand where the organotin(IV) compounds exert their cytotoxicity.	46.43 Lacs + 3.0 Lacs arrears	DBT, New Delhi	Prof. P. Roy, Department of Biosciences and Bio-engineering
NMR Structural and Biophysical Studies on binding of anthraquinone derivatives with Guanine-Quadrupl	08 Aug 2018	NMR Structural and Biophysical Studies of anthraquinone derivatives	Telomerase enzyme involved in maintenance of telomeres is activated in more than 80% of cancer cells, but is absent in normal cells. So targeting telomerase maintenance mechanism could potentially halt tumor growth across a broad spectrum of tumor types with little cytotoxicity/side effects. Telomeric DNA sequences form four stranded Guanine quadruplex DNA structures. In addition, promoters of oncogenes (responsible for uncontrollable growth in cancer tissues) and other regions in genome contain Guanine quadruplex DNA. Small molecules causing stabilization of their structure by binding could act as effective drugs for anticancer action/gene regulation. We have undertaken a study of interaction of Guanine quadruplex DNA with mitoxantrone and its anthraquinone based derivatives synthesized in our laboratory. We find that binding of mitoxantrone alters circular dichroism, absorption and fluorescence spectra significantly. The external binding of ligands along grooves with binding energy of -6 to -9 kcal/mole is accompanied by hydrogen bond formation leading to thermal stabilization of human and Tetrahymena telomeric DNA by 13 and 6°C, respectively. This may interfere with association of telomerase with telomere and hence telomere dysfunction leading to apoptosis in rapidly proliferating cells. We are presently investigating action of diethyl/dimethyl/amido anthraquinone compounds to improve efficacy of anticancer action.	Rs. 44.2272 lakh	DBT, New Delhi	Prof. Ritu Barthwal: PI
Hydrogen storage using activated carbon based materials incorporated with metal-organic compounds	15 May 2008	Activated carbon based materials for Hydrogen storage		Rs. 9,00,000.00	MHRD	Dr. K. Murugesan
QSAR and solution studies of organotin- peptides/nucleotides	15 Sep 2001	Organotin- peptides/-nucleotides		Rs. 13,42,308.00	Department of Science and Technology, New Delhi	nil
Extraction and determination of Mo, Pd and Pt by using Schiff bases	01 Jun 2001	Extraction of Mo, Pd and Pt by using Schiff bases		Rs. 3,89,560.00	University grants commission (UGC), New Delhi	nil
Synthesis, structural and biological activity of organotin compounds	15 Mar 1999	Organotin compounds and their biological utility		Rs. 2,25,000.00	Council of Science & Technology, U.P., Lucknow	nil
New organotin derivatives of amino acids and peptides:Synthesis,characterization, antitumor activity	27 Jan 1994	Organotin derivatives of amino acids and peptides		Rs. 2,61,600.00	UGC	nil
Synthesis,structural and biological studies on organometallic compounds ofSi, Sn and Pb of S-ligands	25 Mar 1991	Organometallic compounds of Si, Sn and Pb with S-ligands		Rs. 1,66,000.00	CSIR	nil
Studies on Reactivity of metal and organometal complexes of Schiff Bases of amino acids	22 Sep 1987	Oganometal complexes of Schiff bases		Rs. 49,700.00	Council of Science & Technology, U.P., Lucknow	Prof. C.L.Sharma
Role of transition metals in chemical evolution	01 Apr 1987	Chemical evolution		Rs. 4,87,000.00	DST, New Delhi	Prpf. Kamaluddin