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E. Gnanamani
Assistant Professor
Research Interests

Educational Details
Professional Background


Honours and Awards

Teaching Engagements
Teaching Engagements

Associate Scholars

Administrative Positions
Research Interests
Organic Chemistry, Organic Synthesis, Asymmetric Catalysis:, Design and Synthesis of New Chiral Catalyst for Organo and Transition Metal Catalysis, Classical Resolution and Determination of Absolute Configuration of Chiral Compounds, ., Total Synthesis of Biologically Active Molecules, ., Microdroplet Reaction, Accelerate the Organic Reaction Rate by Utilizing the Microdroplet Chemistry
Educational Details
Pondicherry University, Pondicherry
Ph.D., Chemistry
Pondicherry University, Pondicherry
M.Phil., Chemistry
Madurai Kamaraj University, Madurai
M.Sc., Chemistry
University of Madars, Chennai
B.Sc., Chemistry
Professional Background
Post Doctoral Fellow
01 Jan 2018 - 01 Jan 2020
Stanford University, USA
Post Doctoral Visiting Fellow (6 months)
01 Jan 2017 - 01 Jan 2018
Fudan University (From Stanford University)
Post Doctoral Fellow
01 Jan 2015 - 01 Jan 2017
Stanford University, USA (Sponsored by Fulbright Foundation)
Post Doctoral Fellow
01 Jan 2013 - 01 Jan 2014
Institute of Chemistry Chinese Academy of Sciences, China

1.      E. Gnanamani, X. Yan, R. N. Zare* "Chemoselective N-alkylation of Indoles in Aqueous Droplets", Angew. Chem. Int. Ed. 202059, 3069-3072; Angew. Chem. 2020132, 3093–3096.

2.        B. M. Trost,* E. Gnanamani, "Enantio- and Diastereoselective Double Mannich Reaction between Ynones and Imines Catalyzed by Zn-ProPhenol", Org. Lett. 2020221675-1680.

3.       B. M. Trost,* Chao-I Hung, G.  Mata, Y. Liu, Y. Lu, E. Gnanamani,  “Direct Enantio- and Diastereoselective Zn-ProPhenol Catalyzed Mannich Reactions of CF3- and SCF3-Substituted Ketones”, Org. Lett. 2020, 22, 2437-2442.

4.       B. M. Trost,* E. Gnanamani, C. A. Kalnmals, Chao-I Hung, J. Tracy, "Direct Enantio- and Diastereoselective Vinylogous Addition of Butenolides to Chromones", J. Am. Chem. Soc. 2019, 141, 1489-1493.

5.      B. M. Trost,* E. Gnanamani, Chao-I Hung, C. A. Kalnmals, "Synthesis of Chiral, Densely Substituted Pyrrolidones via Phosphine-Catalyzed Cycloisomerization", Org. Lett. 201921, 1890-1894.

6.     B. M. Trost,* Chao-I Hung, E. Gnanamani, “Tuning the Reactivity of Ketones through Unsaturation: Construction of Cyclic and Acyclic Quaternary Stereocenters", ACS Catalysis2019, 9, 1549-1557.

7.        E. D.  C. Noriega, S. Sathyamoorthi, S. Banerjee, E. Gnanamani, R. H. Pando, D. M. Espinoza, J. I. V. Bucheli, L. D. Possani, R. N. Zare* "Isolation, Synthesis, and Biological Activity of Non-Peptide Compounds from Diplocentrus melici Scorpion Venom", Proc. Natl. Acad. Sci. U S A. 2019116, 12642-12647.

8.        B. M. Trost,* Chao‐I Hung, T. Saget, E. Gnanamani “Branched Aldehydes as Linchpins for the Enantioselective and Stereodivergent Synthesis of 1,3-Aminoalcohols Featuring a Quaternary Stereocentre", Nature Catalysis, 2018, 1, 523-530.

9.        S. Banerjee, E. Gnanamani, S. Lynch, Z. Zamudio, J,-V. Fernando, V. Jimenez, L. Possani, R. N. Zare,* "An Alkaloid from Scorpion Venom: Chemical Structure and Synthesis", J. Nat. Prod.  201881, 1899-1904.

10.    B. M. Trost,* E. Gnanamani, J. S. Tracy, C. A. Kalnmals "Zn-ProPhenol Catalyzed Enantio- and Diastereoselective Direct Vinylogous Mannich Reaction Between α,β- and β, γ-Butenolides and Aldimines", J. Am. Chem. Soc. 2017139, 18198-18201.

11.       B. M. Trost,* E. Gnanamani, "Chao-I Hung “Controlling Regioselectivity in the Enantioselective N-Alkylation Reaction of Indoles Analogs Catalyzed by Dinuclear Zinc-ProPhenol”, Angew. Chem. Int. Ed. 201756, 10451-10456; Angew. Chem. 2017129,10587–10592.

12.    S. Banerjee, E. Gnanamani, X. Yan, R. N. Zare* "Can all Bulk-Phase Reactions be Accelerated in Microdroplets?", Analyst 2017142,1399-1402 (Cover Article).

13.     G. S. Kiran, S. Priyadharshini, A. D. Dobson, E. Gnanamani, J. Selvin,* "Degradation Intermediates of Polyhydroxy Butyrate Inhibits Phenotypic Expression of Virulence Factors and Biofilm Formation in Luminescent Vibrio sp. PUGSK8", npj Biofilms and Microbiomes (nature partner journal) 2016, 16002.

14.      G. S. Kiran, S. Priyadharshini, K. Anitha, E. Gnanamani, J. Selvin,*  “Characterization of an Exopolysaccharide from Probiont Enterobacter Faecalis MS112 and Effect on the Disruption of Candida Albucans Biofilm", RSC Advances 20155, 71573-71585.

15.     E. Gnanamani, N. Someshwar, J. Sanjeevi, C. R. Ramanathan,* “Conformationally Rigid Chiral Bicyclic Skeleton-Tethered Bipyridine N,N′-Dioxide as Organocatalyst: Asymmetric Ring Opening of meso-Epoxides”, Adv. Synth. Catal. 2014, 356, 2219-2223.

16.      A. Harikrishnan, J. Selvakumar, E. Gnanamani, S. Bhattacharya and C. R. Ramanathan,* “Friedel–Crafts Hydroxyalkylation Through Activation of a Carbonyl Group Using AlBr3: An Easy Access to Pyridyl Aryl/Heteroaryl Carbinols”, New J. Chem.201337, 563-567.

17.      E. Gnanamani, N. Someshwar, C. R. Ramanathan,* “Conformationally Rigid Chiral Pyridine N-Oxides as Organocatalyst: Asymmetric Allylation of Aldehydes”, Adv. Synth. Catal. 2012, 354, 2101-2106.

18.      E. Gnanamani, C. R. Ramanathan,* “Design, Synthesis, Resolution, and Stereochemical Assignment of a Conformationally Rigid Chiral Ligand Derived from Anthracene and a Dienophile Containing a Pyridine Moiety”, Tetrahedron: Asymmetry 200920, 2211-2215.


            Scorpion Venom Benzoquinone Derivatives and uses Thereof Against Multi-Drug Resistant Tuberculosis US Patent       WO 2019/231735 A


Honors And Awards
Stanford University
Fulbright Award
Institute of Chemistry Chinese Academy of Sciences
Developing Country Fellowship for International Researchers Award
Fulbright Alumni
15 Aug 2020 - Present
American Chemical Society
15 Aug 2020 - Present
Teaching Engagements
Teaching Engagements
Organic Chemistry IV ( CYN-523 )
Other work
- Ph.D. and Post Doctoral positions are available, interested candidates can send an e-mail.