Research Interests
Synthetic Organic Chemistry, Chemical Biology, Macrocyclic Peptides, Peptidomimetics, RNA Display, Antimicrobial Drug Discovery, Aqueous Chemistry
BioSketch
Research
Nucleotide-mediated catalytic peptide synthesis from aminonitriles
2026
Luis Ohlendorf, Jyoti Singh, Erica Park, Sofija Spric, Qian Zhang, Josh Maiklem, Daniel Whitaker, Matthew W. Powner*, James Attwater* | ACS
Journal: ChemRxiv
Thioester-mediated RNA aminoacylation and peptidyl-RNA synthesis in water
2025
Jyoti Singh, Benjamin Thoma, Daniel Whitaker, Max Satterly Webley, Yuan Yao, Matthew W. Powner | Nature
Journal: Nature
Prebiotically plausible chemoselective pantetheine synthesis in water
2024
Jasper Fairchild, Saidul Islam, Jyoti Singh, Dejan-Krešimir Bučar, Matthew W. Powner* | Science
Journal: Science
The P(III)‐Amidite Based Synthesis of Stable Isotope Labeled mRNA‐Cap‐Structures Enables their Sensitive Quantitation from Brain Tissue
2024
Alexander Ripp, Martina Krämer, Vanessa Barth, Patrick Moser, Thomas M. Haas, Jyoti Singh, Tamara Huck, Lukas Gleue, Kristina Friedland, Mark Helm, Henning J. Jessen* | Wiley
Journal: Angewandte Chemie (Angew. Chem.)
Prebiotic Catalytic Peptide Ligation Yields Proteinogenic Peptides by Intramolecular Amide Catalyzed Hydrolysis Facilitating Regioselective Lysine Ligation in Neutral Water
2022
Jyoti Singh,† Daniel Whitaker,† Benjamin Thoma, Saidul Islam, Callum S. Foden, Abil E. Aliev, Tom D. Sheppard, Matthew W. Powner* | ACS
Journal: Journal of Amercian Chemical Society (JACS)
Intracellular polyphosphate length characterization in polyphosphate accumulating microorganisms (PAOs): Implications in PAO phenotypic diversity and enhanced biological phosphorus removal performance
2021
Dongqi Wang, Yueyun Li , Helen A. Cope, Xiaoxiao Li, Peisheng, Cong Liu, Guangyu Li, Sheikh M. Rahman, Nicholas B. Tooker, Charles B. Bott, Annalisa Onnis-Hayden, Jyoti Singh, et. al. | Elsevier
Journal: Water Research
Four phosphates at one blow: access to pentaphosphorylated magic spot nucleotides and their analysis by capillary electrophoresis
2020
Thomas M Haas†, Danye Qiu†, Markus Häner, Larissa Angebauer, Alexander Ripp, Jyoti Singh, Hans-Georg Koch, Claudia Jessen-Trefzer, Henning J Jessen* | ACS
Journal: Journal of organic chemistry (JOC)
Rapid Synthesis of Nucleoside Triphosphates and Analogues
2020
Jyoti Singh,† Alexander Ripp,† Henning J. Jessen* | Wiley
Journal: Current Protocol Nucleic Acid Chemistry
Cyclotriphosphate: A Brief History, Recent Developments, and Perspectives in Synthesis
2019
Dominik Bezold, Tobias Dürr, Jyoti Singh, Henning J. Jessen* | Wiley
Journal: Chemistry-A European Journal
Synthesis of Modified Nucleoside Oligophosphates Simplified: Fast, Pure, and Protecting Group Free
2019
Jyoti Singh, Alexander Ripp, Thomas M. Haas, Danye Qiu, Manfred Keller, Paul A. Wender, Jay S. Siegel,* Kim K. Baldridge,* Henning J. Jessen* | ACS
Journal: Journal of Amercian Chemical Society (JACS)
A Phosphoramidite Analogue of Cyclotriphosphate Enables IterativePolyphosphorylations
2019
Jyoti Singh, Nicole Steck, Debaditya De, Alexandre Hofer, Alexander Ripp, Ilya Captain,Manfred Keller, Paul A. Wender, Rashna Bhandari, Henning J. Jessen* | Wiley
Journal: Angewandate Chemie (Angew. Chem)
Several Polyphosphate Kinase 2 Enzymes Catalyse the Production of Adenosine 5'-Polyphosphates
2019
Jyoti Singh,† Silja Mordhorst,† Michael K. F. Mohr, Rahel Hinkelmann, Michael Keppler, Henning J. Jessen*, Jennifer N. Andexer* | Wiley
Journal: ChemBioChem
Screening a Protein Array with Synthetic Biotinylated Inorganic Polyphosphate to Define the Human PolyPome
2018
Cristina Azevedo, Jyoti Singh, Nicole Steck, Alexandre Hofer, Felix A. Ruiz, Tanya Singh, Henning J. Jessen*, Adolfo Saiardi* | ACS
Journal: ACS Chemical Biology (ACS Chem. Biol.)
Design, Synthesis and Biological Evaluation of Novel Spiro[indole-pyridothiazine] Analogues as Antiproliferative Agents
2014
Arya Kapil; Pooja Tomar; Jyoti Singh | Wiley
Journal: ChemInform
Honors And Awards
Teaching Engagements
Miscellaneous
Are you passionate about Organic Synthesis, Chemical Biology, Peptide Chemistry, and Antimicrobial Drug Discovery?
Motivated and enthusiastic researchers interested in PhD and postdoctoral opportunities are encouraged to reach out to discuss potential research opportunities and collaborations.
📩 Get in touch: jyoti.singh@cy.iitr.ac.in
Previous Research Featured in Over 100 News Outlets:
https://nature.altmetric.com/details/180651303/news
https://www.telegraphindia.com/health/clue-to-life-origin-paradox-scientist-reveals-how-lifes-key-molecules-came-together-prnt/cid/2120060
