Prof. Shailly Tomar
Areas of interest - Indian medicinal microbiology; Natural products as antivirals, antimicrobials, and immunomodulators; Gomutra based therapeutics; Developing Phage Therapy- The Ganga holy water
Ongoing Research: Prof. Shailly Tomar’s Molecular Virology laboratory in the Dept. of Biosciences and Bioengineering, IIT Roorkee is working extensively for scientifically validating the known medicinal properties of various Ayurvedic medical plants. Natural products from Indian medicinal sources are investigated and evaluated for their potential to combat and cure emerging vector borne and respiratory viral pathogens namely, Chikungunya virus (CHIKV), Dengue virus, and SARS-CoV-2 etc. For over 15 years, her laboratory has been at the forefront of antiviral research achieving significant milestones in this field as evident from the research publications and patent record. Equipped with both BSLII and BSLIII facilities, the laboratories are handling various infectious viruses, and are well-equipped with equipments for conducting molecular biology, microbiology, in vitro and in vivo studies. Her practical teachings foster critical thinking and analytical skills among students and actively engages them with invaluable hands-on experiences.
Interestingly the group has discovered potent antiviral compounds against coronaviruses from natural sources like Neem and Ashwagandha to cure SARS-CoV-2 infections and the immunomodulatory effects of these have also been assessed with promising results. The group has also identified a therapeutic protein from seeds of Tamarind, commonly known as Imli, and a patent for the efficacy of the antiviral composition containing this protein has been recently granted.
Further, piperine, an alkaloid from black pepper, and thymoquinone, a natural compound isolated from kalonji seeds have been identified as having antiviral potential for the treatment of viral infections. With computational, biophysical, biochemical, and in vitro cell-based assays, the detailed antiviral mechanism of these molecules is decoded.
Additionally, using a combination of molecular identification, separation and virology techniques, the group is executing a research project on Gomutra usage against various viral infections: such as Chikungunya and Dengue.
Her laboratory is actively conducting a research project investigating bacteriophages in the Ganga water to combat drug-resistant bacterial infections. This project aims to develop phage therapy for various applications, including clinical research and the agriculture industry.